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Translation efficiency in the mouse liver upon 24h chow or ketogenic diet fed

ABSTRACT: Translation efficiency in the mouse liver upon 24h chow or ketogenic diet fed

PROVIDER: PRJNA1111095 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29008431_1.fastq.gz	Fastqsanger.gz
	SRR29008431_2.fastq.gz	Fastqsanger.gz
	SRR29008432_1.fastq.gz	Fastqsanger.gz
	SRR29008432_2.fastq.gz	Fastqsanger.gz
	SRR29008433_1.fastq.gz	Fastqsanger.gz

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Translation efficiency in the mouse liver upon 24h chow or ketogenic diet fed

Project description:To investigate the translatome in the ketogenic diet fed condition and the role of phosphoralated eIF4E in it We performed polysome sequencing on chow fed and 24h ketogenic diet fed wild type mice and chow fed eIF4E S209A/S209A mice

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Translation efficiency in the mouse liver upon 24h fasting

Project description:Translation efficiency in the mouse liver upon 24h fasting

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Transcription profiling of mouse livers from animals fed a ketogenic diet (KD), a diet high in fat and low in carbohydrates

Project description:Analysis of liver gene transcription during feeding of a ketogenic diet. Ketogenic diets may alter physiologic and metabolic profiles in a direction that favors weight loss. C57BL/6J mice were maintained for six weeks on either chow or ketogenic diet. Mice eating KD had lower weights, 90% reduction in insulin levels and increased energy expenditure compared to animals fed chow. Despite consumption of a very high fat diet serum lipids remained normal. Here we show that consumption of KD shifted liver metabolism to drastically increased fatty acid oxidation. Concurrently, expression of genes involved in fatty acid synthesis were markedly suppressed. Reference: A high fat, ketogenic diet induces a unique metabolic state in mice. Kennedy AR, Pissios P, Out H, Xue B, Asakura K, Furukawa N, Marino FE, Liu FF, Kahn BB, Liberman TA, Maratos-Flier E. in press, 2007, Am J Physiol Metab 292. Experiment Overall Design: Eight week old C57BL/6 mice were fed either chow (Labdiet 5008, Pharmserv) or KD (F3666, Bio-Serv) for six weeks. Livers were harvested in the morning in ad lib fed animals. Total RNA from 2-3 animals in each group was used for Affymetrix analysis.

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Kainic acid-administered Rat brain: control vs Ketogenic diet-fed

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A high fat, ketogenic diet induces a unique metabolic state in mice.

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Translation efficiency in the pancreatic tumor in response to ketogenic diet and targeting eIF4E phosphorylation

Project description:Translation efficiency in the pancreatic tumor in response to ketogenic diet and targeting eIF4E phosphorylation

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