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ST36 acupuncture ameliorates immune cell proliferation and polarization by inhibiting sympathetic activity in rheumatoid arthritis

ABSTRACT: ST36 acupuncture ameliorates immune cell proliferation and polarization by inhibiting sympathetic activity in rheumatoid arthritis

PROVIDER: PRJNA1112165 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29064362_1.fastq.gz	Fastqsanger.gz
	SRR29064362_2.fastq.gz	Fastqsanger.gz
	SRR29064363_1.fastq.gz	Fastqsanger.gz
	SRR29064363_2.fastq.gz	Fastqsanger.gz
	SRR29064364_1.fastq.gz	Fastqsanger.gz

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ST36 acupuncture ameliorates immune cell proliferation and polarization by inhibiting sympathetic activity in rheumatoid arthritis

Project description:To investigate the upstream mechanism of anti-inflammatory effects of ST36 acupuncture, including regulatory mechanism on T cell proliferation and polarization in peripheral immune organs, and whether peripheral sympathetic innervation in immune organs mediates the autoimmune response modulation by acupuncture.

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Rheumatoid Arthritis Rat Model Treated with Acupuncture

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Affymetrix Chip data of the transcriptome of human clinical study for acupuncture mechanisms on rheumatoid arthritis

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Short Read Sequencing Data of the Transcriptome of the Rheumatoid Arthritis and Treated with Acupuncture or not

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Gene expression data from thalamic regions of MPTP-intoxicated mouse brain by acupuncture

Project description:Acupuncture stimulations at GB34 and LR3 inhibit the reduction of tyrosine hydroxylase in the nigrostriatal dopaminergic neurons in the parkinsonism animal models. Especially, behavioral tests showed that acupuncture stimulations improved the motor dysfunction in a previous study. The thalamus is a crucial area for the motor circuit and has been identified as one of the most markedly damaged areas in Parkinson’s disease (PD), so acupuncture stimulations might also have an effect on the thalamic damage. We investigated gene expression profile changes in the thalamic region of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism models after acupuncture at the acupoints GB34 and LR3 C57BL/6 mice were divided into four experimental groups; ① C: Control, ② M: MPTP-treatment only, ③ MA: MPTP- and acupuncture-treatment at acupoints GB34 and LR3, ④ MNA: MPTP- and acupuncture-treatment at non-acupoints. Total RNA was isolated from two brains' thalamic regions of each experimental group (4 experimental group × 2 samples of each experimental group = total 8 samples).

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Gene expression data from striatal regions of MPTP-intoxicated mouse brain by acupuncture

Project description:Acupuncture at acupoints GB34 and LR3 has been reported to inhibit nigrostriatal degeneration in parkinsonism models, yet the genes related to this preventive effect of acupuncture on the nigrostriatal dopaminergic system remain elusive. We investigated gene expression profile changes in the striatal region of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism models after acupuncture at the acupoints GB34 and LR3 C57BL/6 mice were divided into four experimental groups; â C: Control, â¡ M: MPTP-treatment only, â¢ MA: MPTP- and acupuncture-treatment at acupoints GB34 and LR3, â£ MNA: MPTP- and acupuncture-treatment at non-acupoints. Total RNA was isolated from two brains' striatal regions of each experimental group (4 experimental group Ã 2 samples of each experimental group = total 8 samples).

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Gene expression data from cervical spinal cord regions of MPTP-intoxicated mouse by acupuncture

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