Foxp1 developing neocortex (snRNA-Seq)
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1112386 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:The transcription factor Foxp1 is expressed in the neocortex with restricted patterns across development. We used single nuclei-RNA sequencing (snRNA-Seq) to determine the cell-type roles of Foxp1 in control and Foxp1 conditional knock-out animals generated by crossing to Emx1.Cre hemizygous mice. Samples were collected at embyonic day (E)13.5, E16.5, and post-natal day (P)0.5.
2025-02-07 | GSE267671 | GEO
Project description:Foxp1 developing neocortex (scATAC-Seq)
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Project description:The transcription factor Foxp1 is expressed in the neocortex with restricted patterns across development. We used single nuclei-ATAC sequencing (snATAC-Seq) to determine the cell-type roles of Foxp1 in control and Foxp1 conditional knock-out animals generated by crossing to Emx1.Cre hemizygous mice. Samples were collected at embyonic day (E)13.5, E16.5, and post-natal day (P)0.5.
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Project description:In the mammalian neocortex, diverse projection neuron types are generated by the same pool of neural progenitors in sequential waves. How neuronal cell type specification is related to developmental timing remains unclear. To determine whether neural progenitor cell heterogenity correlates with neuronal type spcification, we performed single cell RNA sequencing analysis of the developing mouse neocortex (E10.5 through E18.5) by Drop-Seq. We uncovered cellular and molecular diversity among neuroepithelial cells, radial glial cells, intermediate progenitors and neuron types.
2021-03-01 | GSE161690 | GEO
Project description:A specific subpopulation of neural progenitor cells, the basal radial glia cells (bRGCs) of the outer subventricular zone (OSVZ), are thought to have a key role in the evolutionary expansion of mammalian neocortex. In the developing lissencephalic mouse neocortex, bRGCs exist at low abundance and show significant molecular differences from bRGCs in developing gyrencephalic species. Here, we demonstrate that developing mouse medial neocortex, in contrast to the canonically studied lateral neocortex, exhibits an OSVZ and an abundance of bRGCs similar to that in developing gyrencephalic neocortex. Unlike bRGCs in developing mouse lateral neocortex, the bRGCs in medial neocortex exhibit human bRGC-like gene expression, including expression of Hopx, a human bRGC marker. Disruption of Hopx expression in mouse embryonic medial neocortex and forced Hopx expression in mouse embryonic lateral neocortex demonstrate that Hopx is required and sufficient, respectively, for a bRGC abundance as found in developing gyrencephalic neocortex. Taken together, our data identify a novel bRGC subpopulation in developing mouse medial neocortex that is highly related to bRGCs of developing gyrencephalic neocortex.
2018-10-10 | GSE120976 | GEO
Project description:A specific subpopulation of neural progenitor cells, the basal radial glial cells (bRGCs) of the outer subventricular zone (OSVZ), are thought to have a key role in the evolutionary expansion of the mammalian neocortex. In the developing lissencephalic mouse neocortex, bRGCs exist at low abundance and show significant molecular differences from bRGCs in developing gyrencephalic species. Here, we demonstrate that the developing mouse medial neocortex (medNcx), in contrast to the canonically studied lateral neocortex (latNcx), exhibits an OSVZ and an abundance of bRGCs similar to that in developing gyrencephalic neocortex. Unlike bRGCs in developing mouse latNcx, the bRGCs in medNcx exhibit human bRGC-like gene expression, including expression of Hopx, a human bRGC marker. Disruption of Hopx expression in mouse embryonic medNcx and forced Hopx expression in mouse embryonic latNcx demonstrate that Hopx is required and sufficient, respectively, for a bRGC abundance as found in developing gyrencephalic neocortex. Taken together, our data identify a novel bRGC subpopulation in developing mouse medNcx that is highly related to bRGCs of developing gyrencephalic neocortex.
2018-10-10 | GSE121008 | GEO
Project description:Foxp1 was strongly expressed in developing lens, and its knockout in lens resulted in failure of appropriate lens development. By microarray analysis, we examined effects of loss-of Foxp1 for gene expression pattern of lens at P0 developmental stage.
2018-01-17 | GSE93693 | GEO
Project description:This SuperSeries is composed of the SubSeries listed below.
2025-02-07 | GSE267673 | GEO
Project description:Progenitor cell diversity in the developing mouse neocortex
| PRJNA679170 | ENA