Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome [cord_blood]

ABSTRACT: Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome [cord_blood]

PROVIDER: PRJNA1114301 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome [brain]

Project description:Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome [brain]

| PRJNA1114300 | ENA

Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome [blood_imprintome]

Project description:Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome [blood_imprintome]

| PRJNA1114299 | ENA

Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome [blood_epic]

Project description:Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome [blood_epic]

| PRJNA1114126 | ENA

Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome [blood_imprintome]

Project description:Differentially methylated imprint control regions (ICRs) regulate the monoallelic expression of imprinted genes. Their epigenetic dysregulation by environmental exposures throughout life results in the formation of common chronic diseases. Unfortunately, existing Infinium methylation arrays lack the ability to profile these regions adequately. Whole genome bisulfite sequencing (WGBS) is the unique method able to profile these regions, but it is very expensive and it requires not only a high coverage but it is also computationally intensive to assess those To address this deficiency, we developed a custom methylation array containing 22,819 probes. Among them, 9,757 probes map to 1,088 out of the 1,488 candidate ICRs recently described. To assess the performance of the array, we created matched samples processed with the Human Imprintome array and WGBS, which is the current standard method for assessing the methylation of the Human Imprintome. We compared the methylation levels from the shared CpG sites and obtained a mean R2 = 0.569. We also created matched samples processed with the Human Imprintome array and the Infinium Methylation EPIC v2 array and obtained a mean R2 = 0.796. Furthermore, replication experiments demonstrated high reliability (ICC: 0.799-0.945).

2024-11-25 | GSE268073 | GEO

Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome [brain]

2024-11-25 | GSE268075 | GEO

Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome [cord_blood]

2024-11-25 | GSE268074 | GEO

Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome [blood_epic]

2024-11-25 | GSE268070 | GEO

Infinium EPIC Array data for desmoid tumors

Project description:Infinium EPIC Array data for desmoid tumors

| PRJNA1053816 | ENA

Creation and validation of models to predict response to chemotherapy before treatment in serous ovarian cancer

Project description:Creation and validation of models to predict response to chemotherapy before treatment in serous ovarian cancer

| PRJNA658793 | ENA

Infinium Monkeys: Infinium 450K array for the Cynomolgus macaque (Macaca fascicularis) (methylation array)

Project description:Infinium 450K is a hybridization array designed for the human genome, but the relative conservation between the macaque and human genomes makes its use in macaques feasible. We used the Infinium450K array to assay twelve Cynomolgus macaque muscle biopsies and compared it to Reduced Representation Bisulphite Sequencing (RRBS) data generated on the same samples.

2014-06-05 | GSE52944 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data