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Transcriptomic analysis reveals the protective biomarkers of Pien Tze Huang in liver cirrhosis mice model [circRNA]

ABSTRACT: Transcriptomic analysis reveals the protective biomarkers of Pien Tze Huang in liver cirrhosis mice model [circRNA]

PROVIDER: PRJNA1119957 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29275152_1.fastq.gz	Fastqsanger.gz
	SRR29275152_2.fastq.gz	Fastqsanger.gz
	SRR29275153_1.fastq.gz	Fastqsanger.gz
	SRR29275153_2.fastq.gz	Fastqsanger.gz
	SRR29275154_1.fastq.gz	Fastqsanger.gz

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Transcriptomic analysis reveals the protective biomarkers of Pien Tze Huang in liver cirrhosis mice model [circRNA]

Project description:Cirrhosis has been one of the major causes of morbidity and mortality worldwide, but safe and effective therapy remains limited. A traditional Chinese medicine, Pien Tze Huang (PTH), has been reported to be effective in protecting the liver. Thus, in this study, we established a mouse cirrhosis model to investigate the effect of PTH on cirrhosis and the potential protective biomarkers using transcriptomic analysis. We identified 1689, 218, 61, and 145 differentially expressed mRNAs, lncRNAs, miRNAs, and circRNAs between the PTH treatment group and the cirrhosis group. Functional enrichment analysis demonstrated that biologically sensible GO terms, such as positive regulation of biological process and response to stimulus, and KEGG pathways, such as IL-17 signaling pathway and Steroid hormone biosynthesis, might be associated with PTH treatment. Similarity analysis based on the drug-induced gene expression profiles of Connectivity Map (version 2) suggested that PTH might have a similar effect to several drugs in clinical trials for cirrhosis. Finally, integration analysis of the competitive endogenous RNA network revealed that eight genes, i.e., P4ha1, Runx1, Inpp5d, Trp53inp1, Rrad, Pkm, Eva1a, and Jun, might be the potential protective biomarkers of PTH against cirrhosis.

2024-06-10 | GSE269012 | GEO

Transcriptomic analysis reveals the protective biomarkers of Pien Tze Huang in liver cirrhosis mice model [mRNA_lncRNA]

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Transcriptomic analysis reveals the protective biomarkers of Pien Tze Huang in liver cirrhosis mice model [miRNA]

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Pien-Tze-Huang Promotes Hepatocellular Carcinoma Cell Ferroptosis by Inhibiting SLC7A11-GSH-GPX4 Axis

Project description:We aimed to evaluate anti-cancer efficacy of Pien-Tze-Huang (PZH), and to investigate the underlying mechanisms by integrating transcriptional regulatory network analysis and experimental validation.

2022-12-31 | GSE221790 | GEO

Protective effect of Pien Tze Huang on colitis-associated colorectal cancer

Project description:The goal of this study is to compare the differentially expressed genes in colon tissue of Control and AOM/DSS induced colitis-associated cancer (CAC) mouse model with or without Pien Tze Huang (PZH) treatment. The AOM/DSS induced CAC mouse model were randomly divided into 2 groups: Model and Model + PZH groups (n=5 for each group). Control mice (n=5) were set as control. mice in Control and Model groups were intragastrically with double distilled water, while mice in PZH and Model + PZH groups were intragastrically with 250 mg/kg/d of PZH for 91 days. Then the colon tissues were used to identify differentially expressed genes among different groups.

2025-01-01 | GSE230302 | GEO

Pien Tze Huang, a traditional Chinese medicine, in maintenance treatment of metastatic colorectal cancer: a prospective, multiple center, randomized, double-blind, placebo-controlled study

Project description:Interventions: Placebo group:Placebo 0.6g bid;Pien Tze Huang group:Pien Tze Huang 0.6g bid Primary outcome(s): progression free survival Study Design: Randomized parallel controlled trial

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Transcriptome Analysis Reveals Potential Protective Effects and Biomarkers of Pien Tze Huang on CCl4-induced Liver Cancer (circRNA)

Project description:Pien Tze Huang (PZH) is a traditional Chinese medicine which was widely utilized in Asia for hepatic diseases. We construct two groups liver cancer mice model using CCl4, one group using PZH treatment and another group didn?t treatment. We found that the liver functional indices including ALB, ALT and AST were significantly increased in non-PZH treatment group. HE staining showed that inflammation was emerged surrounding the hepatic vein in the non-PZH treatment group, Masson staining revealed that there are blue collagenous fibre surrounding hepatic vein in the non-PZH treatment group, this result indicated that PZH cured the hepatic inflammation and cancer. We performed the mRNA,LncRNA,ciecRNA and miRNA sequencing aim to explore the drug target using PZH treatment on transcriptome level. 478 protein coding transcripts and 68 lncRNA transcripts were differentially expressed. Our research provided potential transcriptional therapeutic target for the clinical treatment using PZH.

2024-05-26 | GSE268335 | GEO

Transcriptomic analysis reveals the protective biomarkers of Pien Tze Huang in liver cirrhosis mice model [mRNA_lncRNA]

Project description:Transcriptomic analysis reveals the protective biomarkers of Pien Tze Huang in liver cirrhosis mice model [mRNA_lncRNA]

| PRJNA1119956 | ENA

Transcriptomic analysis reveals the protective biomarkers of Pien Tze Huang in liver cirrhosis mice model [miRNA]

Project description:Transcriptomic analysis reveals the protective biomarkers of Pien Tze Huang in liver cirrhosis mice model [miRNA]

| PRJNA1119958 | ENA

Protective effect of Pien Tze Huang on colitis-associated colorectal cancer

Project description:Protective effect of Pien Tze Huang on colitis-associated colorectal cancer

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