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Assessing the impact of loss of IRF2 on TASOR2 localization

ABSTRACT: Assessing the impact of loss of IRF2 on TASOR2 localization

PROVIDER: PRJNA1120845 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29307662_1.fastq.gz	Fastqsanger.gz
	SRR29307662_2.fastq.gz	Fastqsanger.gz
	SRR29307663_1.fastq.gz	Fastqsanger.gz
	SRR29307663_2.fastq.gz	Fastqsanger.gz
	SRR29307664_1.fastq.gz	Fastqsanger.gz

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Assessing the impact of loss of IRF2 on the transcriptome

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Assessing the impact of loss of IRF2 on TASOR2 localization

Project description:The HUSH complex preserves genome integrity through the epigenetic repression of invasive genetic elements. However, despite our understanding of HUSH as an obligate complex of three subunits, only loss of MPP8 or Periphilin, but not TASOR, triggers interferon signaling following derepression of endogenous retroelements. Here we resolve this paradox by characterising a second HUSH complex which shares MPP8 and Periphilin but assembles around TASOR2, an uncharacterized paralog of TASOR. Whereas HUSH represses LINE-1 retroelements marked by the repressive histone modification H3K9me3, HUSH2 is recruited by the transcription factor IRF2 to repress interferon-stimulated genes. Mechanistically, HUSH-mediated retroelement silencing sequesters the limited pool of the shared subunits MPP8 and Periphilin, preventing TASOR2 from forming HUSH2 complexes and hence relieving the HUSH2-mediated repression of interferon-stimulated genes. Thus, competition between two HUSH complexes intertwines retroelement silencing with the induction of an immune response, coupling epigenetic and immune aspects of genome defense.

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