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The effects of ELF-1 on gene expression profiles of colonic tissue in DSS colitis at single cell level

ABSTRACT: The effects of ELF-1 on gene expression profiles of colonic tissue in DSS colitis at single cell level

PROVIDER: PRJNA1121317 | ENA |

REPOSITORIES: ENA

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Transcription factor ELF-1 protects against colitis by maintaining intestinal epithelium homeostasis

Project description:Inflammatory bowel disease (IBD) is a chronic, relapsing, and remitting disease characterized by chronic inflammation in the gastrointestinal tract. The exact etiology and pathogenesis of IBD remain elusive. Although ELF-1 has been known to be highly expressed in epithelial cells for past twenty years, little is known about its function in epithelial cells and epithelial-related IBD. Here, we demonstrated that ELF-1 deficiency in mouse lead to exacerbated DSS-induced colitis, marked by inflammation dominated by neutrophil infiltration and activation of IL-17 signaling pathways in various immune cells, including Th17, ILC3, γδT and NKT cells. Bone marrow transfer experiments confirmed ELF-1 deficiency in non-hematopoietic cells intrinsically worsened DSS-induced colitis. On one hand, ELF-1 deficiency enhanced the production of pro-inflammatory chemokines in colonic epithelial cells, leading to extensive infiltration of neutrophils and other immune cells into the colonic mucosal tissue. On the other hand, ELF-1 directly regulated the expression of the Rack1 gene in colonic epithelial tissue, which has been proved to play critical roles in maintaining intestinal homeostasis. Altogether, ELF-1 plays a protective role in colitis by maintaining intestinal epithelium homeostasis.

2025-02-12 | GSE289183 | GEO

The effects of ELF-1 on gene expression profiles of colonic tissue in DSS colitis at single cell level

Project description:The maintenance of intestinal homeostasis is closely related to the epithelial integrity and permeability.Elf-1 has been shown to play an important role in the development and maintenance of various hematopoietic lineages,as well as in the regulating the function of endothelial cells during tumor angiogenesis.Here, we characterized the intestinal cell landscape in DSS-induced model with Elf-1 deficiency at the single-cell level, and uncovered the disruption of intestinal immune homeostasis associated with Elf-1 deficiency.

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miRNome of colonic crypt stem cells from DSS-induced colitis mice

Project description:To identify potential unique miRs that contribute to shaping the intestinal stemness in colitis, we analyzed the miRNome of colonic crypt stem cells from DSS-induced colitis mice.

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Temporal transcriptional profiles of colonic tissue during DSS-induce colitis

Project description:Inflammation dramatically alters the gut microenvironment. To investigate the transcriptome changes the temporal profile of multiple signaling pathways throughout the progression of colitis, we collected the colonic tissue at a series of time points during DSS colitis for bulk RNA sequencing.

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Colonic gene expression data of acute and chronic dextran sodium sulphate (DSS) colitis mice

Project description:The lack of suitable animal models reflecting chronically relapsing inflammation and tissue remodeling have hindered fibrosis research in inflammatory bowel diseases (IBD). This study investigated changes in connective tissue in a chronic murine model using different cycles of dextran sodium sulphate (DSS) to mimic the relapsing nature of the disease. We used whole gene expression arrays to study differences in colonic gene expression levels between acute and more chronic DSS colitis, Acute and chronic relapsing colonic inflammation was induced in C57BL6 female mice using several cycles of exposure to DSS in drinking water, followed by recovery phases. Total RNA, extracted from snap frozen colon from five mice per condition was used to analyze mRNA expression via Affymetrix Mouse Gene 1.0 ST arrays.

2013-09-03 | E-GEOD-42768 | biostudies-arrayexpress

Colonic gene expression data of acute and chronic dextran sodium sulphate (DSS) colitis mice

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Transcriptomic anlaysis of the early response of the colonic epithelium to colitis induction by dextran sodium sulfate (DSS)

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Temporal transcriptional profiles of colonic tissue during DSS-induce colitis

Project description:Temporal transcriptional profiles of colonic tissue during DSS-induce colitis

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Cell atlas of colon tissue from DSS-induced colitis mouse

Project description:Inflammation markedly alters the microenvironment of intestinal tissue. To explore alterations in the cell composition and transcription of intestinal tissue during colitis, we conducted single-cell RNA sequencing analysis of the colonic tissues obtained from the mice treated with 3% DSS for 6 days.

2024-05-28 | GSE268235 | GEO

Mechanisms research on Cyanidin-3-O-glucoside ameliorating dextran sulfate sodium (DSS)-induced colitis.

Project description:TMT proteomics for colonic mucosa in DSS-induced colitis mice with or without administrated Cyanidin-3-O-glucoside was used for discovery of differential expressed proteins.

2023-07-10 | PXD043662 |

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