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Surufatinib increases cholangiocarcinoma cells radiosensitivity by anti-tumor proliferation and inhibition of macrophage M2 polarization

ABSTRACT: Surufatinib increases cholangiocarcinoma cells radiosensitivity by anti-tumor proliferation and inhibition of macrophage M2 polarization

PROVIDER: PRJNA1122142 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29344180_1.fastq.gz	Fastqsanger.gz
	SRR29344180_2.fastq.gz	Fastqsanger.gz
	SRR29344181_1.fastq.gz	Fastqsanger.gz
	SRR29344181_2.fastq.gz	Fastqsanger.gz
	SRR29344182_1.fastq.gz	Fastqsanger.gz

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Surufatinib increases cholangiocarcinoma cells radiosensitivity by anti-tumor proliferation and inhibition of macrophage M2 polarization

Project description:This study confirmed the radiosensitizing effects of surufatinib on cholangiocarcinoma. The mechanism is that surufatinib can activate TLR3, up-regulate the expression of TRIF protein, increase DNA damage and apoptosis after radiation, and up-regulate NF- κB signal pathway to inhibit M2 polarization of tumor-associated macrophages, thus enhance radiosensitivity.

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