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The gene expression of adipose stem cells obtained from donors of varying ages

ABSTRACT: The gene expression of adipose stem cells obtained from donors of varying ages

PROVIDER: PRJNA1124015 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29412309_1.fastq.gz	Fastqsanger.gz
	SRR29412309_2.fastq.gz	Fastqsanger.gz
	SRR29412310_1.fastq.gz	Fastqsanger.gz
	SRR29412310_2.fastq.gz	Fastqsanger.gz
	SRR29412311_1.fastq.gz	Fastqsanger.gz

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The gene expression of adipose stem cells obtained from donors of varying ages

Project description:In the current investigation, a comprehensive analysis using high-throughput RNA sequencing (RNA-seq) was carried out on ADSCs obtained from donors of varying ages. 678 genes showed differential expression between ADSCs obtained from young and old donors (Y-ADSCs and O-ADSCs), with 47 of these genes being TFs. The findings indicated that 316 genes exhibited decreased expression levels, while 362 genes displayed increased expression levels in O-ADSCs in comparison to Y-ADSCs. Subsequent analyses using GO and KEGG were performed to further elucidate the roles of the identified differentially expressed genes. The GO analysis revealed that these genes are predominantly localized in the plasma membrane and extracellular region, serving as constituents of the extracellular matrix and participating in protein binding. Additionally, they are implicated in processes related to cell adhesion and signal transduction pathways. KEGG analysis indicated enrichment in pathways such as neuroactive ligand-receptor interaction, calcium signaling, pathways in cancer, ErbB signaling, and cell adhesion molecules.

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Project description:Dedifferentiated Fat Cells (DAs) and Adipose-derived stem cells (ADSCs) are two main stem cells derived from adipose tissue. In order to explore whether there is difference in transcriptome between the two cells after multiple subcultures, and which kind of cell should be selected for different regenerative aim, high-throughput RNAseq were conducted to find differentially expressed genes. The subcutaneous adipose tissue of three young women (23-30 years old)patients with normal BMI (19-24) were obtained during liposuction operation on abdomen or thigh. Stromal Vascular Fraction (SVF) and adipocytes were obtained by collagenase digestion, ADSCs was cultured regularly, and DAs were cultured by a modified ceiling culture method. Only 186 genes with different expression between the two groups were obtained.The downregulated gene number of DAs vs. ADSCs was 112 and the upregulated number was 74. Many of the differentially expressed genes are involved in the biological functions such as transcription regulator, protein translation regulation, cytokine interaction and energy metabolism regulation. These data may provide a foundation for further clinical administration of stem cells derived from adipose tissues.

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