Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Streptococcus pyogenes

ABSTRACT: GAS WGS (Georgia Department of Public Health)

PROVIDER: PRJNA1126729 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR29585437_1.fastq.gz	Fastqsanger.gz
	SRR29585437_2.fastq.gz	Fastqsanger.gz
	SRR29585438_1.fastq.gz	Fastqsanger.gz
	SRR29585438_2.fastq.gz	Fastqsanger.gz
	SRR29585439_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 100

Similar Datasets

Haemophilus influenzae

Project description:H. influenzae WGS (Georgia Department of Public Health)

| PRJNA1143046 | ENA

Neisseria meningitidis

Project description:N. meningitidis WGS (Georgia Department of Public Health)

| PRJNA1137890 | ENA

Georgia Department of Public Health

Project description:SARS CoV-2 WGS (Georgia Department of Public Health)

| PRJNA713775 | ENA

Invasive Streptococcus pyogenes

Project description:WGS of invasive GAS

| PRJEB64433 | ENA

Streptococcus pyogenes MGAS5005: control vs heme exposure

Project description:Transcriptional profiling of Streptococcus pyogenes MGAS5005 cells comparing control untreated GAS cells with GAS cells exposed to 4uM heme for 1.5 h

2014-09-16 | GSE61415 | GEO

Streptococcus pyogenes MGAS5005: control vs heme exposure

Project description:Transcriptional profiling of Streptococcus pyogenes MGAS5005 cells comparing control untreated GAS cells with GAS cells exposed to 4uM heme for 1.5 h Two-condition experiment, untreated vs. heme-treated MGAS5005 cells. Biological replicates: 3 control, 3 Heme-treated, independantly grown and harvested. One replicate per array.

2014-09-16 | E-GEOD-61415 | biostudies-arrayexpress

Streptococcus pyogenes

Project description:GAS gene expression from mouse-passaged and clinical GAS strains

| PRJNA94149 | ENA

RNAseq transcriptome analysis of Streptococcus pyogenes HKU16 and an isogenic gshT mutant. Manuscript title: Streptococcus pyogenes hijacks host glutathione for growth and innate immune evasion

Project description:The nasopharynx and the skin are the major oxygen-rich anatomical sites for colonization by the human pathogen Streptococcus pyogenes (group A Streptococcus, GAS). To establish infection, GAS must survive oxidative stress generated during aerobic metabolism and the release of reactive oxygen species (ROS) by host innate immune cells. Glutathione is the major host antioxidant molecule while GAS is glutathione-auxotrophic. Here we report the molecular characterization of the ABC transporter substrate binding protein GshT in the GAS glutathione salvage pathway. We demonstrate that glutathione uptake is critical for aerobic growth of GAS and that impaired import of glutathione induces oxidative stress that triggers enhanced production of the reducing equivalent NADPH. Our results highlight the interrelationship between glutathione assimilation, carbohydrate metabolism, virulence factor production and innate immune evasion. Together, these findings suggest an adaptive strategy employed by extracellular bacterial pathogens to exploit host glutathione stores for their own benefit.

2022-04-04 | GSE198061 | GEO

Proteome analysis of extracellular vesicles released from Streptococcus pyogenes

Project description:Streptococcus pyogenes (Group A Streptococcus: GAS) is a major human pathogen that causes streptococcal pharyngitis, skin and soft-tissue infections, and life-threatening conditions such as streptococcal toxic shock syndrome (STSS). A large number of virulence-related genes are encoded on GAS genomes, which are involved in host-pathogen interaction, colonization, immune invasion, and long-term survival within hosts, causing the diverse symptoms. Here, we investigated the interaction between GAS-derived extracellular vesicles and host cells in order to reveal pathogenicity mechanisms induced by GAS infection.

2021-05-17 | PXD026040 | JPOST Repository

Campylobacter jejuni

Project description:GenomeTrakr Project: Massachusetts Department of Public Health

| PRJNA369525 | ENA