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The Alb-R26Met liver cancer mouse model recapitulates molecular features and heterogeneity of hepatocellular carcinoma patients

ABSTRACT: The Alb-R26Met liver cancer mouse model recapitulates molecular features and heterogeneity of hepatocellular carcinoma patients

PROVIDER: PRJNA1132968 | ENA |

REPOSITORIES: ENA

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The Alb-R26Met liver cancer mouse model recapitulates molecular features and heterogeneity of hepatocellular carcinoma patients

Project description:We have generated an inside-out genetic mouse model of liver cancer, the Alb-R26Met mice, in which slightly increased levels of the wild-type form of the MET Receptor Tyrosine Kinase (RTK) occurs specifically in the liver following the deletion of a stop cassette by the Cre recombinase. This genetic combination is obtained by crossing the R26stopMet with Alb-Cre mice. The Alb-R26Met mice spontaneously develop liver tumours and model the whole tumorigenic program. These tumours correspond to HCC patients belonging to the proliferative-progenitor subset. Importantly, the Alb-R26Met model recapitulates several features of HCC patients, including the molecular heterogeneity, the temporal heterogeneity of tumour onset, and the resistance to RTK inhibitors used in the clinic for HCC treatment. This unique genetic setting offered us the possibility to compare the transcriptomic profile of Alb-R26Met non-tumoral livers with Alb-R26Met advanced liver tumours. Outcomes offer an overall vision of how gene expression switches during a tumorigenic process modelled by the Alb-R26Met mice. Importantly, as tumorigenesis in the Alb-R26Met genetic setting occurs in an immune-competent context, outcomes offers as well the possibility to explore the profound changes in the immune microenvironment in the liver tumours, by performing deconvolution of RNAseq data.

2025-02-07 | GSE271709 | GEO

Spatial tissue proteomics quantifies inter- and intra-tumor heterogeneity in hepatocellular carcinoma

Project description:The inter-patient variability of tumor proteomes has been investigated on a large scale but many tumors display also intra-tumoral heterogeneity (ITH) regarding morphological and genetic features. To what extent the local proteome of tumors intrinsically differs remains largely unknown. Here, we used hepatocellular carcinoma (HCC) as a model system, to quantify both inter- and intra-tumor heterogeneity across human patient specimens with spatial resolution. We first defined proteomic features that robustly distinguish neoplastic from the directly adjacent non-neoplastic tissue by integrating proteomic data from human patient samples and genetically defined mouse models with available gene expression data. We then demonstrated the existence of intra-tumoral variations in protein abundance that re-occur across different patient samples, and affect clinically relevant proteins, even in the absence of obvious morphological differences or genetic alterations. Our work demonstrates the suitability and the benefits of using mass spectrometry based proteomics to analyze diagnostic tumor specimens with spatial resolution

2018-01-24 | PXD007052 | Pride

Molecular heterogeneity of multinodular hepatocellular carcinoma

Project description:Molecular heterogeneity of multinodular hepatocellular carcinoma

| PRJNA273840 | ENA

Brachypodium distachyon strain:Alb-AL2D | cultivar:Alb-AL2D

Project description:Brachypodium distachyon strain:Alb-AL2D | cultivar:Alb-AL2D Genome sequencing

| PRJNA333719 | ENA

Brachypodium distachyon strain:Alb-AL2F | cultivar:Alb-AL2F

Project description:Brachypodium distachyon strain:Alb-AL2F | cultivar:Alb-AL2F Genome sequencing

| PRJNA333721 | ENA

Brachypodium distachyon strain:Alb-AL2E | cultivar:Alb-AL2E

Project description:Brachypodium distachyon strain:Alb-AL2E | cultivar:Alb-AL2E Genome sequencing

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3D Intercellular Assembly of Decellularized Matrix Recapitulates In Vivo Tumor Heterogeneity

Project description:3D Intercellular Assembly of Decellularized Matrix Recapitulates In Vivo Tumor Heterogeneity

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Brachypodium distachyon strain:Alb-AL1A.1 | cultivar:Alb-AL1A.1

Project description:Brachypodium distachyon strain:Alb-AL1A.1 | cultivar:Alb-AL1A.1 Genome sequencing

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Murine hepatocellular carcinoma of MCL1-/- transgenic mice and age matched alb cre mice - 12 months old.

Project description:aCGH analysis of murine transgenic liver tissues affected with HCC, hybridized with age (12 months) and sex matched alb cre mice. Keywords: Array comparative genomic hybridization analysis (aCGH).

2009-12-31 | GSE16580 | GEO

Integrated multiomic analysis reveals comprehensive tumor heterogeneity in primary and recurrent hepatocellular carcinomas

Project description:The tumor heterogeneity between the primary and recurrent hepatocellular carcinoma (HCC) has rarely been explored. The present study aims to illustrate the heterogeneity between the primary and recurrent tumors by integrating multiomic analyses.

2023-01-06 | GSE164359 | GEO

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