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A Trisomy 21 Lung Cell Atlas

ABSTRACT: A Trisomy 21 Lung Cell Atlas

PROVIDER: PRJNA1136930 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29866213.fastq.gz	Fastqsanger.gz
	SRR29866214.fastq.gz	Fastqsanger.gz
	SRR29866215.fastq.gz	Fastqsanger.gz
	SRR29866216.fastq.gz	Fastqsanger.gz
	SRR29866217.fastq.gz	Fastqsanger.gz

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A Trisomy 21 Lung Cell Atlas

Project description:Trisomy 21 (T21), resulting in Down Syndrome (DS), is the most prevalent chromosomal abnormality worldwide. While pulmonary disease is a major cause of morbidity and mortality in DS, the ontogeny of pulmonary complications remains poorly understood. We recently demonstrated that T21 lung anomalies, including airway branching and vascular lymphatic abnormalities, are initiated in utero. Here, we aimed to describe molecular changes at the single cell level in prenatal T21 lungs. Our results demonstrate differences in the proportion of cell populations and detail changes in gene expression at the time of initiation of histopathological abnormalities. Notably, we identify shifts in the distribution of alveolar epithelial progenitors, widespread induction of key extracellular matrix molecules in mesenchymal cells and hyper-activation of IFN signaling in endothelial cells. This single cell atlas of T21 lungs greatly expands our understanding of antecedents to pulmonary complications and should facilitate efforts to mitigate respiratory disease in DS.

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Project description:Gene expression was measured in trisomy 21 and trisomy 13 human fetal samples. For TS21, regions assayed were cerebrum, cerebellum, heart, and cerebrum-derived astrocyte cell lines. Keywords = trisomy 21 Keywords = Down syndrome Keywords = aneuploidy Keywords = brain Keywords = heart Keywords = trisomy 13 Keywords: other

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Crnic Institute Human Trisome Project - Trisomy 21 Model Atlas: PolyA RNA-seq from C57BL/6 and Dp16 adult mouse lung tissue ± JAK1/2 inhibition with baricitinib

Project description:Analysis of steady-state mRNA levels in adult mouse lung tissue at 7-11 weeks from wild-type C57BL/6 and Dp16 mice ± treatment with the JAK1/2 inhibitor baricitinib. This dataset is part of the Human Trisome Project - Trisomy 21 Model Atlas run by the Linda Crnic Institute for Down Syndrome at the University of Colorado Anschutz Medical Campus. http://www.trisome.org/

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