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Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice

ABSTRACT: Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice

PROVIDER: PRJNA1138415 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29907351.fastq.gz	Fastqsanger.gz
	SRR29907352.fastq.gz	Fastqsanger.gz
	SRR29907353.fastq.gz	Fastqsanger.gz
	SRR29907354.fastq.gz	Fastqsanger.gz
	SRR29907355.fastq.gz	Fastqsanger.gz

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Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice

Project description:Genetic variation is known to contribute to the variation of animal social behavior, but the molecular mechanisms that lead to behavioral differences are still not fully understood. Here, we investigate the cellular evolution of the hypothalamic medial preoptic area (MPOA), a brain region that plays a critical role in social behavior, across two sister species of deer mice (Peromyscus maniculatus and P. polionotus) with divergent social systems. These two species exhibit large differences in mating and parental care behavior across species and sex. Using single-nucleus RNA-sequencing, we build a molecular atlas of the MPOA for males and females of both Peromyscus species.

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Transcription profiling of mouse bed nucleus of the stria terminalis and medial preoptic area

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Glucoregulatory responses to hypothalamic preoptic area cooling.

Project description:Normal glucose homeostasis depends on the capacity of pancreatic β-cells to adjust insulin secretion in response to a change of tissue insulin sensitivity. In cold environments, for example, the dramatic increase of insulin sensitivity required to ensure a sufficient supply of glucose to thermogenic tissues is offset by a proportionate reduction of insulin secretion, such that overall glucose tolerance is preserved. That these cold-induced changes of insulin secretion and insulin sensitivity are dependent on sympathetic nervous system (SNS) outflow suggests a key role for thermoregulatory neurons in the hypothalamic preoptic area (POA) in this metabolic response. As these POA neurons are themselves sensitive to changes in local hypothalamic temperature, we hypothesized that direct cooling of the POA would elicit the same glucoregulatory responses that we observed during cold exposure. To test this hypothesis, we used a thermode to cool the POA area, and found that as predicted, short-term (8-h) intense POA cooling reduced glucose-stimulated insulin secretion (GSIS), yet glucose tolerance remained unchanged due to an increase of insulin sensitivity. Longer-term (24-h), more moderate POA cooling, however, failed to inhibit GSIS and improved glucose tolerance, an effect associated with hyperthermia and activation of the hypothalamic-pituitary-adrenal axis, indicative of a stress response. Taken together, these findings suggest that POA cooling is sufficient to recapitulate key glucoregulatory responses to cold exposure.

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