Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB [SLAM seq in J1 ES]

ABSTRACT: Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB [SLAM seq in J1 ES]

PROVIDER: PRJNA1138738 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB [5mC in ES and EB]

Project description:Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB [5mC in ES and EB]

| PRJNA903112 | ENA

Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB [SLAM seq in J1 ES]

Project description:Marking of DNA, histones, and RNA is central to gene expression regulation in development and disease. Recent evidence links m6A, installed on RNA by the METTL3-METTL14 methyltransferase complex, to histone modifications, but the link between m6A and DNA methylation remains scarcely explored. This study shows that METTL3-METTL14 recruits the DNA methyltransferase DNMT1 to chromatin for gene-body methylation. We identify a set of genes whose expression is fine-tuned by both gene-body 5mC, which promotes transcription, and m6A, which destabilizes transcripts. We demonstrate that METTL3-METTL14-dependent 5mC and m6A are both essential for the differentiation of embryonic stems cells to embryoid bodies and that the upregulation of key differentiation genes during early differentiation depends on the dynamic balance between increased 5mC and decreased m6A. Our findings add a surprising new dimension to our understanding of how epigenetics and epitranscriptomics combine to regulate gene expression and impact development, most likely among other biological processes.

2025-01-10 | GSE272791 | GEO

Comparison of Gene Expression Profiles of J1 ES and J1 EB Cells.

Project description:Comparison of gene expression profiles of J1 embryonic stem cells and J1 embryoid bodies. This study should reveal genes that, when expressed, are responsible for the maintenance of the stem cell phenotype. Keywords: other

2005-09-01 | GSE3223 | GEO

Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB [PROseq in E14TG2a ES/EB]

Project description:Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB [PROseq in E14TG2a ES/EB]

| PRJNA1138741 | ENA

Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB [m6A in ES and EB and RNAseq in EB]

Project description:Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB [m6A in ES and EB and RNAseq in EB]

| PRJNA903111 | ENA

Transcription profiling of mouse J1 ES and J1 EB cells

2008-11-06 | E-GEOD-3223 | biostudies-arrayexpress

Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB [RNAseq in Mettl14KO and rescued in E14TG2a ES/EB]

Project description:Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB [RNAseq in Mettl14KO and rescued in E14TG2a ES/EB]

| PRJNA1138740 | ENA

Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB [ActinoD in E14TG2a ES]

Project description:Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB [ActinoD in E14TG2a ES]

| PRJNA1138725 | ENA

Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB

Project description:Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB

| PRJNA766061 | ENA

DR4 Control for J1, R1 and V6.5 ES

Project description:This sample is a control for the J1, R1 and V6.5 ES samples. The DR4 cell type acts as a feeder cell for stem cells and as such is a small contaminant of the embryonic stem cell growth environment. Keywords: other

2005-09-01 | GSE3232 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data