Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1138742 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Phoca vitulina Transcriptome or Gene expression
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Project description:Harbor seal (Phoca vitulina) genome sequencing and assembly
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Project description:Characterising the gut microbiome of stranded harbour seals (Phoca vitulina) in rehabilitation.
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Project description:Quantitative evaluation of intraspecific genetic diversity in a natural fish population using environmental DNA analysis
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Project description:DNA methylation is an epigenetic modification, influenced by both genetic and environmental variation, that plays a key role in transcriptional regulation and many organismal phenotypes. Although patterns of DNA methylation have been shown to differ between human populations, it remains to be determined how epigenetic diversity relates to the patterns of genetic and gene expression variation at a global scale. Here we measured DNA methylation at 485,000 CpG sites in five diverse human populations, and analyzed these data together with genome-wide genotype and gene expression data. We found that population-specific DNA methylation mirrors genetic variation, and has greater local genetic control than mRNA levels. We estimated the rate of epigenetic divergence between populations, which indicates far greater evolutionary stability of DNA methylation in humans than has been observed in plants. This study provides a deeper understanding of worldwide patterns of human epigenetic diversity, as well as initial estimates of the rate of epigenetic divergence in recent human evolution.
2017-08-01 | GSE101431 | GEO
Project description:Detection of genetic diversity of a fish population using environmental DNA analysis: Analysis strategies for eliminating sequencing artifacts
| PRJDB6813 | ENA
Project description:Genetic variation is regarded as a prerequisite for evolution. Theoretical models suggest epigenetic information inherited independently of DNA sequence can also enable evolution. However, whether epigenetic inheritance mediates phenotypic evolution in natural populations is unknown. Here we show that natural epigenetic DNA methylation variation in gene bodies regulates genes expression, and thereby influences the natural variation of complex traits in Arabidopsis thaliana. Notably, the effects of methylation variation on phenotypic diversity and gene expression variance are comparable with those of DNA sequence polymorphism. We also identify methylation epialleles in numerous genes associated with environmental conditions in native habitats, suggesting that intragenic methylation facilitates adaptation to fluctuating environments. Our results demonstrate that methylation variation fundamentally shapes phenotypic diversity in natural populations and provides an epigenetic basis for adaptive Darwinian evolution independent of genetic polymorphism.
2022-06-30 | GSE183785 | GEO