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Methylation and Transcriptomic Profiling Reveals Short Term and Long Term Regulatory Responses in Polarized Macrophages [RNA-Seq]

ABSTRACT: Methylation and Transcriptomic Profiling Reveals Short Term and Long Term Regulatory Responses in Polarized Macrophages [RNA-Seq]

PROVIDER: PRJNA1142532 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30058566_1.fastq.gz	Fastqsanger.gz
	SRR30058566_2.fastq.gz	Fastqsanger.gz
	SRR30058567_1.fastq.gz	Fastqsanger.gz
	SRR30058567_2.fastq.gz	Fastqsanger.gz
	SRR30058568_1.fastq.gz	Fastqsanger.gz

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Methylation and Transcriptomic Profiling Reveals Short Term and Long Term Regulatory Responses in Polarized Macrophages.

Project description:Methylation and Transcriptomic Profiling Reveals Short Term and Long Term Regulatory Responses in Polarized Macrophages.

| PRJNA1142525 | ENA

Methylation and Transcriptomic Profiling Reveals Short Term and Long Term Regulatory Responses in Polarized Macrophages [RNA-Seq]

Project description:Macrophage plasticity allows the adoption of distinct functional states in response to environmental cues. While unique transcriptomic profiles define these states, focusing solely on transcription neglects potential long-term effects. The investigation of epigenetic changes can be used to understand how temporary stimuli can result in lasting effects. Moreover, epigenetic alterations play an important role in the pathophysiology of macrophages, including phenomena related to the trained innate immunity, which allow faster and more efficient inflammatory responses upon subsequent encounters with the same pathogen. In this study, we used a multi-omics approach to elucidate the interplay between gene expression and DNA-methylation, unravelling the long-term effects of diverse polarizing environments on macrophage activity. We identified a common core set of genes that are differentially methylated regardless of exposure suggesting a potential mechanism for rapid adaptation to various stimuli. These conserved epigenetic modifications might represent a fundamental state that allows for flexible responses to various environmental cues. Functional analysis revealed that processes requiring rapid responses displayed transcriptomic regulation, whereas functions critical for long-term adaptations exhibited co-regulation at both transcriptomic and epigenetic levels. Our study unveils a novel set of genes critically linked to the long-term effects of macrophage polarization. This discovery underscores the potential of epigenetics in elucidating how macrophages establish long-term memory and influence health outcomes.

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Distinct transcriptional responses across tissue-resident macrophages to short-term and long-term metabolic challenge

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Distinct transcriptional responses across tissue-resident macrophages to short-term and long-term metabolic challenge

Project description:Distinct transcriptional responses across tissue-resident macrophages to short-term and long-term metabolic challenge

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Short and long term cold responses in a winter barley

Project description:Gene expression changes in a winter cultivar of barley in response to short and long term cold treatments ****[PLEXdb(http://www.plexdb.org) has submitted this series at GEO on behalf of the original contributor, Ben Trevaskis. The equivalent experiment is BB94 at PLEXdb.] treatment: Non-vernalized (3-replications); treatment: Short-term cold (3-replications); treatment: Vernalized (3-replications); treatment: 1 day post-vernalized (3-replications)

2011-03-08 | E-GEOD-27821 | biostudies-arrayexpress

Short and long term cold responses in a winter barley

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Methylation and Transcriptomic Profiling Reveals Short Term and Long Term Regulatory Responses in Polarized Macrophages.

Project description:This SuperSeries is composed of the SubSeries listed below.

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microRNA expression profiling of polarized macrophages

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2017-08-10 | E-MTAB-5458 | biostudies-arrayexpress

Canine Polarized Macrophages Express Distinct Functional and Transcriptomic Profiles

Project description:in the present study we investigate polarized canine macrophages using transcriptome sequencing, a larger panel of flow cytometry markers, and antimicrobial functional assays. Transcriptome analysis of primary canine monocyte-derived macrophages revealed unique, previously unreported signatures for polarized M1 and M2 macrophages.

2022-09-30 | GSE207661 | GEO

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