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RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [smallRNA-seq]

ABSTRACT: RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [smallRNA-seq]

PROVIDER: PRJNA1145379 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30163300_1.fastq.gz	Fastqsanger.gz
	SRR30163300_2.fastq.gz	Fastqsanger.gz
	SRR30163301_1.fastq.gz	Fastqsanger.gz
	SRR30163301_2.fastq.gz	Fastqsanger.gz
	SRR30163302_1.fastq.gz	Fastqsanger.gz

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RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [smallRNA-seq]

Project description:The centromere is a pivotal chromatin domain that ensures accurate chromosome segregation during cell division. However, the epigenome regulation of the centromere and its impact on centromere function remain largely elusive. Here in the model plant Arabidopsis, we show that CCR4, the catalytic subunit of the RNA deadenylation complex CCR4-NOT, is essential for maintenance of the centromere epigenome and chromosome integrity. We demonstrate that CCR4 is involved in shortening of the poly(A) tails of transcripts originated from centromeric transposons and repeats, thereby promoting the production of small interfering RNAs (siRNAs). The CCR4-dependent siRNAs guide non-CG DNA methylation at centromere repeats, and CCR4 cooperates with canonical DNA methylation pathways to enhance centromeric H3K9 methylation and ensure mitotic chromosome stability. Our study illustrates the crucial role of RNA quality control in RNA interference and reveals the elaborate mechanism that safeguards plant centromeres through epigenomic regulation.

2024-08-24 | GSE274192 | GEO

RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [EM-seq]

2024-08-24 | GSE274196 | GEO

RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [ChIP-seq]

2024-08-24 | GSE274190 | GEO

RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [RNA-seq]

2024-08-24 | GSE274191 | GEO

RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [Oxford Nanopore Technology Direct RNA Sequencing]

2024-08-24 | GSE274200 | GEO

RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [RNA-seq]

Project description:RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [RNA-seq]

| PRJNA1145380 | ENA

RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [ChIP-seq]

Project description:RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [ChIP-seq]

| PRJNA1145381 | ENA

RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [EM-seq]

Project description:RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [EM-seq]

| PRJNA1145382 | ENA

RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [Oxford Nanopore Technology Direct RNA Sequencing]

Project description:RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [Oxford Nanopore Technology Direct RNA Sequencing]

| PRJNA1145390 | ENA

Heterochromatin integrity affects chromosome reorganization after centromere dysfunction

Project description:The centromere is essential for the inheritance of genetic information on eukaryotic chromosomes. Epigenetic regulation of centromere identity has been implicated in genome stability, karyotype evolution and speciation. However, little is known regarding the manner in which centromere dysfunction affects the chromosomal architectures. Here we show that in the fission yeast Schizosaccharomyces pombe, the conditional deletion of the centromere produces survivors that carry either neocentromere-acquired chromosome at the sub-telomeric region or acentric chromosome rescued by inter-telomere fusion with other chromosome. The ratio of neocentromere formation to telomere fusion is considerably decreased by inactivation of genes involved in RNA interference (RNAi)-dependent heterochromatin formation. By affecting the modes of chromosomal reorganization, the genomic distribution of heterochromatin may influence the fate of karyotype evolution. Keywords: ChIP-chip

2008-08-22 | GSE10287 | GEO

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