Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Network-based bioinformatics highlights broad importance of human milk hyaluronan

ABSTRACT: Network-based bioinformatics highlights broad importance of human milk hyaluronan

PROVIDER: PRJNA1145472 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Network-based bioinformatics highlights broad importance of human milk hyaluronan

Project description:Hyaluronic acid 35 kDa (HA35) is protective against murine necrotizing enterocolitis and is present in high levels in colostrum and early human milk. We utilized pathway and network analysis of bulk RNA-seq transcriptomics of the distal ileum of mouse pups to determine molecular mechanisms through which HA35 may influence small intestinal maturation and protection against inflammatory disease.

2024-12-19 | GSE274261 | GEO

Cultured cardiomyocytes treated with hyaluronan

Project description:Investigation of the role of hyaluronan in cardiomyocytes . The aims of the study were to determine if cardiomyocytes are capable of detecting hyaluronan and if then intrecellular signaling causes changes in gene expression. The study showed that cardiomyocytes can bind hyaluronan with following change in gene expression.

2011-11-01 | GSE21675 | GEO

Gene expression profile of hyaluronan-induced cell clusters in multiple myeloma

Project description:We identified the changes in gene expression profile in hyaluronan-induced spheroids to elucidate the mechanisms of drug resistance of extramedullary disease in multiple myeloma.

2022-07-31 | GSE189364 | GEO

Resident macrophages promote homeostasis of hyaluronan-associated extracellular matrix in the mammary gland stroma

Project description:Tissue resident macrophages in the mammary gland are found in close association with epithelial structures and within the adipose stroma, and are important for mammary gland development and tissue homeostasis. While epithelial-associated macrophages have been linked to ductal development, the contributions of stromal macrophages to mammary gland homeostasis remain unknown. Using transcriptional profiling, we identify a distinct resident stromal macrophage subpopulation that is characterized by expression of Lyve-1, a receptor for the extracellular matrix component hyaluronan. This subpopulation is enriched in genes associated with extracellular matrix remodeling and is found to be specifically associated with hyaluronan-rich regions within the mammary stroma. Furthermore, macrophage depletion leads to increased accumulation of hyaluronan-associated extracellular matrix in the mammary stroma. These results demonstrate the presence of a distinct subpopulation of macrophages and provide insights into the functional contributions of these macrophages to stromal homeostasis in the mammary gland.

2020-05-31 | GSE148207 | GEO

Hyaluronan mediates cold-induced adipose tissue beiging

Project description:Hyaluronan mediates cold-induced adipose tissue beiging

| PRJNA1118733 | ENA

Hyaluronan Control of the Primary Vascular Barrier during Early Mouse Pregnancy is Mediated by Uterine NK Cells

Project description:The goals of this study are to the investigate how uterine NK cells mediate the role of hyaluronan as a vascular morphogen following embryo implantation in mice

2020-08-28 | GSE156979 | GEO

Identification of miRNAs from Eugenia uniflora by high-throughput sequencing and bioinformatics analysis [mRNA-seq]

Project description:miRNAs are small non-coding regulatory RNAs that play important functions in the regulation of gene expression at the post-transcriptional level by targeting mRNAs for degradation or by inhibiting protein translation. Eugenia uniflora is a plant native to tropical America with pharmacological and ecological importance without previous studies about its gene expression and regulation. To date, there is not miRNAs reported in species of Myrtaceae. A small RNA library was constructed to identify miRNAs in Eugenia uniflora. Solexa technology was used to perform high throughput sequencing of the library and the data obtained was analysed using bioinformatics tools. From 14,489,131 clean reads, we obtained 1,852,722 small RNAs representing 45 known miRNA families that have been identified in other plant species. Further analysis using contigs assembled from Illumina mRNA sequencing of leaves from the same individual allowed the prediction of secondary structures of 25 known and 17 novel miRNAs. Potential targets were predicted for the most abundant mature miRNAs in the identified pre-miRNAs based on sequence homology. This study provide the first large scale identification of miRNAs and their potential targets of a species from Myrtaceae without previous genomic sequence resources. Our study provides more information about the evolutionary conservation of the regulatory network of miRNAs in plants and highlights the miRNAs species-specific. mRNA profiles in 1 leaf library of Eugenia uniflora by deep sequencing (Illumina HiSeq2000)

2013-01-07 | E-GEOD-38210 | biostudies-arrayexpress

Identification of miRNAs from Eugenia uniflora by high-throughput sequencing and bioinformatics analysis [small RNA-seq]

Project description:miRNAs are small non-coding regulatory RNAs that play important functions in the regulation of gene expression at the post-transcriptional level by targeting mRNAs for degradation or by inhibiting protein translation. Eugenia uniflora is a plant native to tropical America with pharmacological and ecological importance without previous studies about its gene expression and regulation. To date, there is not miRNAs reported in species of Myrtaceae. A small RNA library was constructed to identify miRNAs in Eugenia uniflora. Solexa technology was used to perform high throughput sequencing of the library and the data obtained was analysed using bioinformatics tools. From 14,489,131 clean reads, we obtained 1,852,722 small RNAs representing 45 known miRNA families that have been identified in other plant species. Further analysis using contigs assembled from Illumina mRNA sequencing of leaves from the same individual allowed the prediction of secondary structures of 25 known and 17 novel miRNAs. Potential targets were predicted for the most abundant mature miRNAs in the identified pre-miRNAs based on sequence homology. This study provide the first large scale identification of miRNAs and their potential targets of a species from Myrtaceae without previous genomic sequence resources. Our study provides more information about the evolutionary conservation of the regulatory network of miRNAs in plants and highlights the miRNAs species-specific. microRNA profiles in 1 leaf library of Eugenia uniflora by deep sequencing (Illumina HiSeq2000)

2013-01-07 | E-GEOD-38211 | biostudies-arrayexpress

Characterization of Holstein and Normande whole milk miRNomes highlights breed specificities

Project description:Characterization of Holstein and Normande whole milk miRNomes highlights breed specificities

| PRJNA556024 | ENA

Blocking hyaluronan synthesis alleviates acute lung allograft rejection.

Project description:Blocking hyaluronan synthesis alleviates acute lung allograft rejection.

| PRJNA759258 | ENA