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Immunocompatible Elastomer with increased resistance to the foreign body response

ABSTRACT: Immunocompatible Elastomer with increased resistance to the foreign body response

PROVIDER: PRJNA1148948 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30274062_1.fastq.gz	Fastqsanger.gz
	SRR30274062_2.fastq.gz	Fastqsanger.gz
	SRR30274063_1.fastq.gz	Fastqsanger.gz
	SRR30274063_2.fastq.gz	Fastqsanger.gz
	SRR30274064_1.fastq.gz	Fastqsanger.gz

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Immunocompatible Elastomer with increased resistance to the foreign body response

Project description:Polymeric elastomers are extensively employed to fabricate implants intended for prolonged implantation. However, implantation of the elastomers can induce strong immune rejection reaction known as foreign body response (FBR), resulting in the rejection of foreign implants and thereby diminishing their in vivo efficacy. Herein, we present a group of immunocompatible elastomers, termed easy-to-synthesize vinyl-based anti-FBR dense elastomers (EVADE), synthesized via a straightforward and scalable method. In contrast to the pronounced immune reaction triggered by the commonly used implantable elastomers, EVADE materials effectively suppress the inflammation and long-term capsule formation in subcutaneous models of rodents and non-human primates for at least one year and two months, respectively. Implantation of EVADE materials significantly reduces the expression of inflammation-related proteins S100A8/A9 in adjacent tissues compared to polydimethylsiloxane (PDMS). We also show that inhibition or knockout of S100A8/A9 leads to substantial attenuation of fibrosis in mice, suggesting a target for fibrosis inhibition. Continuous subcutaneous insulin infusion (CSII) catheters constructed from EVADE elastomers demonstrate significantly improved longevity and performance compared to commercial catheters. The EVADE materials reported here may enhance and extend function in various medical devices by resisting local immune responses to implanted biomaterials.

2024-08-17 | GSE275010 | GEO

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Spatial sequencing of Foreign body granuloma

Project description:Although macrophage-epithelioid cell (EPC)-giant cell (GC) differentiation is acknowledged in foreign body reaction (FBR), the exact molecular features remain elusive. To discover the molecular profiles of EPC and GC, we analyzed mouse sponge and silk FBRs by integrating single-cell RNA-sequencing (scRNA-seq) and spatial sequencing.

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Single-cell Analysis of Surface Topography-induced Foreign Body Response to Silicone Implants

Project description:Single-cell Analysis of Surface Topography-induced Foreign Body Response to Silicone Implants

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Immunocompatible elastomer with increased resistance to the foreign body response.

Project description:Polymeric elastomers are extensively employed to fabricate implantable medical devices. However, implantation of the elastomers can induce a strong immune rejection known as the foreign body response (FBR), diminishing their efficacy. Herein, we present a group of immunocompatible elastomers, termed easy-to-synthesize vinyl-based anti-FBR dense elastomers (EVADE). EVADE materials effectively suppress the inflammation and capsule formation in subcutaneous models of rodents and non-human primates for at least one year and two months, respectively. Implantation of EVADE materials significantly reduces the expression of inflammation-related proteins S100A8/A9 in adjacent tissues compared to polydimethylsiloxane. We also show that inhibition or knockout of S100A8/A9 leads to substantial attenuation of fibrosis in mice, suggesting a target for fibrosis inhibition. Continuous subcutaneous insulin infusion (CSII) catheters constructed from EVADE elastomers demonstrate significantly improved longevity and performance compared to commercial catheters. The EVADE materials reported here may enhance and extend function in various medical devices by resisting the local immune responses.

| S-EPMC11364871 | biostudies-literature

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