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Single CD4 T cell gene expression and T cell receptor profile of human volunteers experimentally infected with malaria

ABSTRACT: single CD4 T cell gene expression and T cell receptor profile of human volunteers experimentally infected with malaria

PROVIDER: PRJNA1149089 | ENA |

REPOSITORIES: ENA

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single CD4 T cell gene expression and T cell receptor profile of human volunteers experimentally infected with malaria

Project description:Human volunteers were experimentally infected with Plasmodium falciparum blood-stage malaria parasites in the context of the VAC063C experimental medicine study (ClinicalTrials.gov NCT03906474). The gene expression profile and T cell receptor alpha and beta chains of CD4 T cells were analysed at single cell resolution at baseline (before malaria infection) and six days after treatment (at the peak of the circulating T cell response). We are comparing the T cell response to the first malaria infection of life (with the highest risk of severe disease) and the third infection where disease tolerance is established. This single cell data is complemented by bulk RNAseq data of flow sorted CD4 T cell subsets (naive, memory and regulatory) available through the GEO SuperSeries GSE172481.

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RNAseq of nasal cells from volunteers experimentally infected with RSV

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Molecular Hallmarks of Experimentally Acquired Immunity to Malaria [Pilot Study]

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Molecular Hallmarks of Experimentally Acquired Immunity to Malaria [Pilot Study]

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RNAseq of nasal cells from volunteers experimentally infected with RSV

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RNAseq of nasal cells from pre-symptomatic volunteers experimentally infected with RSV

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Transcription profiling of human peripheral blood mononuclear cell gene expression patterns in presymptomatic and clinically apparent malaria

Project description:Using genome-wide expression profiles from persons either experimentally challenged with malaria-infected mosquitoes or naturally-infected with Plasmodium falciparum malaria, we present details of the transcriptional changes that occur with infection and that are either commonly shared between subjects with pre-symptomatic and clinically apparent malaria or that distinguish these two groups. Our findings confirm and extend aspects of the earliest responses to malaria infection at the molecular level and which may be informative in elucidating how innate and adaptive immune responses may be modulated in different stages of infection. Experiment Overall Design: Compared samples from patients with naturally acquired malaria infection to those from volunteers in a challenge model vaccine trial.

2007-11-01 | E-GEOD-5418 | biostudies-arrayexpress

Transcriptional responses in whole blood of healthy adult volunteers experimentally challenged with S. Typhi

Project description:In this study, whole blood samples were used to determine the gene expression of healthy adult volunteers experimentally challenged with S. Typhi Quailes strain. Samples were collected at baseline (pre-challenge; Group: CTRL) and 7 days after challenge (Group: sEF) in individuals who did not reach diagnostic criteria. In those reaching the diagnostic endpoint (typhoid fever; Group: EF) the sample on the day of diagnosis when antibiotic treatment commenced was taken. These samples were derived from the placebo arm of a recent a Single Centre, Randomised, Doubleblind, Placebo Controlled Study to Evaluate M01ZH09 in a Healthy Adult Challenge Model, Using Ty21a Vaccine as a Positive Control. Darton et al. PMID: 27533046.

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Project description:We report the analysis of nasal curettage cells by RNAseq collected at pre-symptomatic timepoints in healthy adults experimentally challenged with respiratory syncytial virus (RSV). Following inoculation, 57% of participants developed PCR-confirmed infection. Prior to viral challenge, 80 differentially expressed genes were identified that associated with susceptibility to symptomatic infection. At day 3, 87 differentially expressed genes were associated with protection. Thus, we showed that the nasal mucosa at the time of virus exposure and during the incubation phase correlate with susceptibiltiy and protection from respiratory viral infection.

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