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Metabolic Reprogramming of Iron Endows the Function of ISCA2-TET Interaction During Peri-implantation Development

ABSTRACT: Metabolic Reprogramming of Iron Endows the Function of ISCA2-TET Interaction During Peri-implantation Development

PROVIDER: PRJNA1150498 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30327400_1.fastq.gz	Fastqsanger.gz
	SRR30327400_2.fastq.gz	Fastqsanger.gz
	SRR30327393_1.fastq.gz	Fastqsanger.gz
	SRR30327393_2.fastq.gz	Fastqsanger.gz
	SRR30327394_1.fastq.gz	Fastqsanger.gz

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Metabolic Reprogramming of Iron Endows the Function of ISCA2-TET Interaction During Peri-implantation Development

Project description:Metabolic reprogramming plays important roles in embryo development. However, the metabolic network has still not been systematically investigated during the processes. In this study, we develop MFE, a metabolites flux estimation tool, to predict metabolite abundances and their regulons, highlighting the role of Fe(II) and its regulon-ISCA2, in the inner cell mass (ICM) of human and mouse blastocysts. By introducing Isca2-/-, Isca2G77S/G77S and Isca2C144S/C144S mice, we find ISCA2 binding with iron, but not Fe-S cluster, is indispensable for mouse peri-implantation development. Mechanistically, nuclear ISCA2 interacts with TET, and Fe(II) is important for the interaction by triggering the enzymatic activity of TET. The partnership safeguards promoters of epiblast-specific genes from hypermethylation and is essential for epiblast development in mouse peri-implantation embryos. The study provides insights into how iron metabolism modulates embryo development, and suggests a manner of Fe(II)-dependentenzymes to achieve activity under physiological conditions.

2024-08-27 | GSE275340 | GEO

Metabolic Reprogramming of Iron Endows the Function of ISCA2-TET Interaction During Peri-implantation Development (EM-Seq)

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Metabolic Reprogramming of Iron Endows the Function of ISCA2-TET Interaction During Peri-implantation Development (EM-Seq)

Project description:Metabolic Reprogramming of Iron Endows the Function of ISCA2-TET Interaction During Peri-implantation Development (EM-Seq)

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Murine uterus expression profile during Peri-implantation: Pre-implantation vs. Post-implantation

Project description:Anaylsis differentially expressed genes of mouse peri-implanted uteri comparing pre-implantation uteri (Day2, Day3 and Day4) with post-implantation uteri (Day6, Day7 and Day8) by microassay. This study has built a meaningful basis for future investigation in elucidating the molecular nature of maternal-fetal interactions during pregnancy establishment and maintenance. Pre-implantation uteri VS. Post-implantation uteri. Three biological replicates of each experiments: pre-implantation uteri (Day2, Day3 and Day4): 234, 234①, 234②; 3 mixture of post-implantation uteri (Day6, Day7 and Day8): 678, 678①, 678②. Two hybridizations were performed by using a reverse fluorescence strategy (Cy3, Cy5) for each sample.

2011-06-30 | E-GEOD-26615 | biostudies-arrayexpress

Murine uterus expression profile during Peri-implantation: Pre-implantation vs. Post-implantation

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microRNA expression profile in peri-implantation porcine embryos

Project description:Recently, microRNAs (miRNAs) have emerged as new players in the fine tuning of embryo development and implantation in mammals via posttranscriptional gene regulation mechanisms. Applying custom made multispecies arrays we aimed to analyze expression profile of microRNAs in peri-implantation porcine conceptuses/trophoblasts to identify their potential role at the maternal-fetal interface during the critical period of maternal recognition of pregnancy and implantation. miRNA expression profiles were analyzed in samples collected from embryos or trophoblast on Days 10, 11, 12, 16 and 20 of pregnancy. Each group was represented by five to nine samples.

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Single-cell trascriptiponal landscapes of bovine peri-implantation development

Project description:Supporting healthy pregnancy outcomes requires a comprehensive understanding of the cellular hierarchy and underlying molecular mechanisms during peri-implantation development. Here, we presented a single-cell transcriptome-wide view of the bovine peri-implantation embryo development at day 12, 14, 16 and 18, when most of the pregnancy failure occurs. We defined the development and dynamic progression of cellular composition and gene expression of embryonic disc, hypoblast, and trophoblast lineages during bovine peri-implantation development. Notably, the comprehensive transcriptomic mapping of trophoblast development revealed a previous unrecognized primitive trophoblast cell lineage that are responsible for pregnancy maintenance in bovine prior to the time when binucleate cell emerges. We analyzed novel markers for the cell lineage development during bovine early development. We also identified cell-cell communication signaling underling embryonic and extraembryonic cells interact to ensure proper early development in bovine. Collectively, our work provides foundational information to discover essential biological pathways underpinning bovine peri-implantation development and the molecular causes of the early pregnancy failure during this critical period.

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microRNA expression profile in peri-implantation porcine embryos

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