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Targeting heterogeneous tumor microenvironments in pancreatic cancer mouse models of metastasis by TGFB depletion

ABSTRACT: Targeting heterogeneous tumor microenvironments in pancreatic cancer mouse models of metastasis by TGFB depletion

PROVIDER: PRJNA1151736 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30358750.fastq.gz	Fastqsanger.gz
	SRR30358751.fastq.gz	Fastqsanger.gz
	SRR30358752.fastq.gz	Fastqsanger.gz
	SRR30358753.fastq.gz	Fastqsanger.gz
	SRR30358754.fastq.gz	Fastqsanger.gz

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Targeting heterogeneous tumor microenvironments in pancreatic cancer mouse models of metastasis by TGFB depletion

Project description:The dual tumor-suppressive and promoting function of TGFB signaling has made its targeting challenging. We hereby examined the effects of TGFB depletion by AVID200/BMS-986416(TGFB-TRAP), a TGFB ligand trap, on the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) murine models with different organ-specific metastasis using single-nuclear RNA-sequencing (snRNA-seq)

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