Project description:Molecular analysis of the spatio-temporal dynamics of destabilization and self-reorganization underscore the crucial role of WNT and BMP signaling modulators as part of the Turing system.

2024-08-30 | GSE275783 | GEO

Synchronization of growth and self-organizing digit pattern by WNT signaling [ChIPseq]

2024-08-30 | GSE275782 | GEO

Sir2 recruitment after synchronization

Project description:Sir2 recruitment after synchronization

| PRJNA923803 | ENA

Self-organizing human trunk 3D neuromuscular organoids

Project description:Self-organizing human trunk 3D neuromuscular organoids

| PRJNA527260 | ENA

Self-organizing pattern of subpleural alveolar ducts.

Project description:In this study we have utilized an optical clearing method to allow visualization of a heretofore undescribed subpleural acinar structural organization in the mammalian lung. The clearing method enables visualization of the lung structure deep below the visceral pleura in intact inflated lungs. In addition to confirming previous observations that the immediate subpleural alveoli are uniform in appearance, we document for the first time that the subpleural lung parenchyma is much more uniformly organized than the internal parenchyma. Specifically, we report that below the surface layer of alveoli, there is a striking parallel arrangement of alveolar ducts that all run perpendicular to the visceral pleural surface. A three dimensional visualization of alveolar ducts allowed for a calculation of the average inner to outer duct diameter ratio of 0.53 in these subpleural ducts. This unique, self-organizing parallel duct structure likely impacts both elastic recoil and the transmission of tethering forces in healthy and diseased lungs.

| S-EPMC7035422 | biostudies-literature

Cadherins modulate the self-organizing potential of gastruloids

Project description:Cadherins modulate the self-organizing potential of gastruloids

| PRJNA1039257 | ENA

Digital gene expression tag profiling of digit morphologies in bats

Project description:As the only truly flying mammals, bats use their unique wing formed from elongated digits connected by membranes to power their flight. The forelimb of bats consists of four elongated digits (digits II-V) and one shorter digit (digit I) that is morphologically similar to the hindlimb digits. Elongation of bat forelimb digits is thought to results from changes in the temporal and spatial expression of a number of developmental genes. As a result, comparing gene expression profiles between short and elongated digit morphologies of the fore- and hindlimbs may elucidate the molecular mechanisms underlying digit elongation in bats. Here, we performed a large-scale analysis of gene expression of forelimb digit I, forelimb digits II-V, and all five hindlimb digits in Myotis ricketti using digital gene expression tag profiling approach. Results of this study not only implicate several developmental genes as robust candidates underlying digit elongation in bats, but also provide a better understanding of the genes involved in autopodial development in general. A large-scale analysis of gene expression of 3 different parts of autopods in Myotis ricketti using digital gene expression tag profiling approach.

2010-12-06 | E-GEOD-20038 | biostudies-arrayexpress

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