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Expression profile of CircRNA in Type2 diabetes mellitus patients with retinopathy

ABSTRACT: Expression profile of CircRNA in Type2 diabetes mellitus patients with retinopathy

PROVIDER: PRJNA1154961 | ENA |

REPOSITORIES: ENA

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Expression profile of CircRNA in Type2 diabetes mellitus patients with retinopathy

Project description:Diabetic retinopathy (DR) is one of the common chronic complications of diabetes. Circular RNA (circRNA) plays a vital role in the pathological process of diabetic retinopathy (DR), this study aims to explore the differences in circRNA expression profiles and functions between DR and non-DR patients.Serum from diabetes mellitus (DM) patients with DR (n=5) and without DR (n=5) were extracted for circRNA microarray analysis using Arraystar Human circRNA expression profile (v2.0). Another 5 DR and 5 non-DR patients were included for quantitative reverse transcription polymerase chain reaction (RT-qPCR) validation. Enriched signaling pathways were analyzed by GO and KEGG analysis. circRNA–miRNA networks were constructed by bioinformatics analysis.

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