Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mesenchymal Stem Cells Generated from Human Urine-derived iPSCs Exhibit Low Immunogenicity and Im-munomodulatory Profile

ABSTRACT: Mesenchymal Stem Cells Generated from Human Urine-derived iPSCs Exhibit Low Immunogenicity and Im-munomodulatory Profile

PROVIDER: PRJNA1156562 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR30541711_1.fastq.gz	Fastqsanger.gz
	SRR30541711_2.fastq.gz	Fastqsanger.gz
	SRR30541712_1.fastq.gz	Fastqsanger.gz
	SRR30541712_2.fastq.gz	Fastqsanger.gz
	SRR30541713_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Mesenchymal Stem Cells Generated from Human Urine-derived iPSCs Exhibit Low Immunogenicity and Im-munomodulatory Profile

Project description:We conducted transcriptome analysis to determine the differences between umbilical cord-derived mesenchymal stem cells (named UCMSC) and iMSCs generated from human urine-derived iPSC (named B6MSC) at the transcriptomic level. The expression of genes related to aging, rejuvenation, proliferation or immune regulatory factors in iMSCs was different significantly from that of UCMSCs.

2024-09-07 | GSE276291 | GEO

Degradome sequencing of urine-derived ADO2-iPSCs

Project description:Degradome sequencing of urine-derived ADO2-iPSCs

| PRJNA553162 | ENA

Urine

Project description:Urine Raw sequence reads

| PRJNA850668 | ENA

IM CD34+ progenitors cells

Project description:IM CD34+ vs BM CD34+ cells Keywords: parallel sample

2006-10-06 | GSE3410 | GEO

Small RNA sequencing of urine-derived ADO2-iPSCs

Project description:Small RNA sequencing of urine-derived ADO2-iPSCs

| PRJNA553161 | ENA

Human Somitoids Generated by Reprogramming Pax8+ Urine Cells

Project description:Human Somitoids Generated by Reprogramming Pax8+ Urine Cells

| PRJNA750787 | ENA

urine metagenome

Project description:urine metagenome Metagenome

| PRJNA1032262 | ENA

urine metagenome

Project description:source-separated urine Metagenome

| PRJNA399057 | ENA

Multiomics Analyses of Vesicular Transport Pathway-Specific Transcripts and Proteins in Ovine Amnion: Responses to Altered Intramembranous Transport

Project description:Amniotic fluid (AF) volume (AFV) is determined primarily by the rate of intramembranous (IM) transport of AF across the amnion. Intramembranous transport is characterized as vesicular endocytotic and transcytotic processes regulated by fetal urine-derived stimulators and AF inhibitors. Our objectives were to utilize a large-scale multiomics approach to decipher the vesicular transport pathways in the amnion and to identify potential transport regulators in AF and fetal urine. We utilized fetal sheep to experimentally induce alterations in IM transport rate and analyze the expression profiles of transcripts and proteins in amnion, AF and fetal urine. Four experimental groups were studied: control (C), urine drainage with reduced IM transport rate and AFV (UD), urine drainage and fluid replacement with decreased IM transport rate but increased AFV (UDR), and intra-amniotic fluid infusion with augmented IM transport rate and AFV (IA). Amnion and fluid samples were subjected to transcriptomics (RNA-Seq) and proteomics studies followed by bioinformatics analyses using Ingenuity Pathway Analysis software. The analyses revealed 9 functional transport pathways and a panel of differentially expressed transcripts and proteins that are known mediators of vesicular transport and energy metabolism. During UD, expressions of endocytosis and trafficking mediators were reduced as compared to controls. Under UDR, expressions of energy metabolism activators increased while trafficking mediators decreased. During IA, expressions of vesicular uptake and transcellular trafficking regulators were enhanced. Co-expression of the motor protein, cytoplasmic dynein light chain-1, in both AF and fetal urine suggest that this molecule may function as a urine-derived stimulator of IM transport.

2019-03-30 | GSE129077 | GEO

Synthesis of immunogenicity-free RNA circles as potent PKR inhibitors

Project description:Exon(s) back-splicing-generated circular RNAs as a group can suppress the double-stranded RNA (dsRNA)-activated protein kinase R (PKR) in cells. We have sought to synthesize immunogenicity-free, short dsRNA-containing circular RNAs as potent PKR inhibitors. Here, we report that circular RNAs synthesized by permuted td introns from T4 bacteriophage and by Anabeana pre-tRNA group I intron induce an immune response. Mechanistically, autocatalytic splicing introduces extra ~74 nt and ~186 nt fragments (E1+E2+spacer) that form additional stable loop structures that likely provoke innate immune responses in circular RNA products. In contrast, circular RNAs produced by T4 RNA ligase without unwanted fragment exhibit little immunogenicity. Importantly, directly-ligated circular RNAs form short dsRNA-regions exhibit 103~106 fold higher efficiency than the reported chemical compounds C16 and 2-AP in suppressing PKR activation, highlighting the use of circular RNAs as novel inhibitors for PKR over-reaction diseases.

2021-12-23 | GSE183941 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data