Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1159384 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Most of Colorectal cancer (CRC) diagnosed are candidates for surgical resection with curative intent, although colorectal surgery is associated with some complications that could be life-threatening. Antibiotic prophylaxis is commonly used prior to the admission for the prevention of postoperative complications. However, this intervention can change the composition of intestinal microbiota and promote adverse inflammatory outcomes in CRC patients after surgery.
It seems the combination of different fungal extracts could be beneficial because of their role in gut microbiota modulation and their anti-inflammatory activity. Therefore, the fungal extract nutraceutical MICODIGEST 2.0 could be used to reduced the complications after CRC surgery.
Based on this hypothesis, we have designed a double-bind randomized clinical trial to evaluate the effect of MICODIGEST 2.0 on the complications after surgery with curative intent for CRC.
| 2372490 | ecrin-mdr-crc
Project description:This study investigates the effects of cyclodipeptide on fungal and nematode metabolism, specifically focusing on its impact on membrane composition and metabolic responses. Metabolomic profiles of treated and untreated fungal cultures were compared to unravel the molecular changes induced by cyclodipeptide, with a particular emphasis on membrane phospholipids such as monoolein and phosphatidyl ethanolamine, as well as other plasma membrane components like ergosterol and its derivative products. The results reveal significant alterations in the metabolites present in the presence of cyclodipeptide. Specifically, the levels of cyclo (Pro-Tyr) monoolein were found to decrease, while phosphatidyl ethanolamine levels increased. Moreover, the levels of ergosterol and its derivatives were observed to decrease as well. These findings indicate that cyclodipeptide has a profound impact on the metabolic pathways of the fungal system under investigation. The study suggests that cyclodipeptide not only influences membrane phospholipids but may also have broader effects on membrane proteins, cellular signaling, and communication. Furthermore, the observed changes in metabolomic profiles hint at potential alterations in cellular processes beyond membrane composition, possibly involving gene expression and enzyme activity. Understanding the mechanisms behind these effects holds considerable scientific interest and practical implications. The ability of cyclodipeptide to selectively target membrane components presents opportunities for studying and manipulating membrane function in various organisms. Additionally, the discovery of new bioactive natural products like cyclodipeptide opens avenues for developing innovative therapeutics or agricultural agents. Further research is needed to fully comprehend the intricate mechanisms underlying the observed effects of cyclodipeptide on fungal metabolism.
2023-07-23 | GSE237225 | GEO
Project description:This study investigates the effects of cyclodipeptide on fungal and nematode metabolism, specifically focusing on its impact on membrane composition and metabolic responses. Metabolomic profiles of treated and untreated fungal cultures were compared to unravel the molecular changes induced by cyclodipeptide, with a particular emphasis on membrane phospholipids such as monoolein and phosphatidyl ethanolamine, as well as other plasma membrane components like ergosterol and its derivative products. The results reveal significant alterations in the metabolites present in the presence of cyclodipeptide. Specifically, the levels of cyclo (Pro-Tyr) monoolein were found to decrease, while phosphatidyl ethanolamine levels increased. Moreover, the levels of ergosterol and its derivatives were observed to decrease as well. These findings indicate that cyclodipeptide has a profound impact on the metabolic pathways of the fungal system under investigation. The study suggests that cyclodipeptide not only influences membrane phospholipids but may also have broader effects on membrane proteins, cellular signaling, and communication. Furthermore, the observed changes in metabolomic profiles hint at potential alterations in cellular processes beyond membrane composition, possibly involving gene expression and enzyme activity. Understanding the mechanisms behind these effects holds considerable scientific interest and practical implications. The ability of cyclodipeptide to selectively target membrane components presents opportunities for studying and manipulating membrane function in various organisms. Additionally, the discovery of new bioactive natural products like cyclodipeptide opens avenues for developing innovative therapeutics or agricultural agents. Further research is needed to fully comprehend the intricate mechanisms underlying the observed effects of cyclodipeptide on fungal metabolism.
2023-07-23 | GSE237224 | GEO
Project description:Rice blast is a recurrent fungal disease, and resistance to fungal infection is a complex trait. Therefore, a comprehensive examination of rice transcriptome and its variation during fungal infection is necessary to understand the complex gene regulatory networks. In this study, adopting Next-Generation Sequencing we profiled the transcriptomes and microRNAomes of rice varieties, one susceptible and the other resistant to M. oryzae, at multiple time points during the fungal infection.
2016-05-01 | GSE77332 | GEO
Project description:Amplicon-based fungal metagenomic sequencing for the identification of fungal species in brain tissue from Alzheimer's disease. The study consists in 14 samples, sequenced using Illumina's paired-end technology.
| EGAD00001003196 | EGA