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CUT&RUN of the aging mouse brain reveals origins of inflammation in the white matter

ABSTRACT: CUT&RUN of the aging mouse brain reveals origins of inflammation in the white matter

PROVIDER: PRJNA1164126 | ENA |

REPOSITORIES: ENA

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Spatial transcriptomics and CUT&RUN of the aging mouse brain reveal origins of inflammation in the white matter

Project description:Spatial transcriptomics and CUT&RUN of the aging mouse brain reveal origins of inflammation in the white matter

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CUT&RUN of the aging mouse brain reveals origins of inflammation in the white matter

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CUT&RUN HUDEP1 OE SOX6-Flag

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2023-04-07 | E-MTAB-12800 | biostudies-arrayexpress

Spatial transcriptomics and CUT&RUN of the aging mouse brain reveal origins of inflammation in the white matter

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-12-31 | GSE284202 | GEO

Identification of chromatin states during zebrafish gastrulation using CUT&RUN and CUT&Tag

Project description:Here we describe successful implementation of CUT&RUN for profiling protein-DNA interactions in zebrafish embryos. We apply modified a CUT&RUN method to generate high resolution maps of enrichment for H3K4me3, H3K27me3, H3K9me3, and RNA polymerase II during zebrafish gastrulation. Using this data, we identify a conserved subset of developmental genes that are enriched in both H3K4me3 and H3K27me3 during gastrulation, and we demonstrate the increased effectiveness of CUT&RUN for detecting protein enrichment at repetitive sequences with reduced mappability. Our work demonstrates the power of combining CUT&RUN with the strengths of the zebrafish system to better understand the changing embryonic chromatin landscape and its roles in shaping development.

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