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ABSTRACT: Research on the change of intestinal flora composition in rate modelling of the deficiency syndrome of lung and spleen Qi

PROVIDER: PRJNA1166090 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30816700_1.fastq.gz	Fastqsanger.gz
	SRR30816700_2.fastq.gz	Fastqsanger.gz
	SRR30816701_1.fastq.gz	Fastqsanger.gz
	SRR30816701_2.fastq.gz	Fastqsanger.gz
	SRR30816702_1.fastq.gz	Fastqsanger.gz

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Effect of Supplementing Qi and strengthening spleen on the expression of TTR in serum of patients with colorectal carcinoma and its correlation with the dynamic changes of syndrome

Project description:Interventions: Syndrome of spleen qi deficiency1:Chinese medicine of Supplementing Qi and nourishing spleen;Syndrome of spleen qi deficiency2:no;Flat syndrome group:no;Qi deficiency constitution:no Primary outcome(s): Symptom score;Serum TTR expression Study Design: Case-Control study

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Multi-group analysis of TCM syndrome types of patients with colorectal cancer

Project description:Interventions: Patients with spleen deficiency and qi stagnation syndrome SDQSS:NA;Patients with DHS with damp-heat accumulation syndrome:NA;Patients with SPOS with stasis and internal resistance syndrome:NA;Patients with SKYDS of Spleen and Kidney Yang Deficiency Syndrome:NA;Patients with liver-kidney yin deficiency syndrome LKYDS:NA;QBDS patients with deficiency of both qi and blood syndrome:NA Primary outcome(s): Serum metabolites;Fecal microbiome;lipidomics Study Design: Diagnostic test for accuracy

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Application of gut microbiota in dynamic evaluation of TCM syndromes and canceration in patient with colorectal tumor

Project description:Interventions: Colorectal adenoma (excessive syndrome: intestinal damp-heat syndrome) group:None;Colorectal adenoma (deficiency syndrome: spleen and stomach deficiency syndrome) group:None;Colorectal cancer (excessive syndrome: damp-heat accumulation syndrome) group:None;Colorectal cancer (deficiency syndrome: spleen deficiency and qi stagnation syndrome) group:None;Healthy control group:None Primary outcome(s): Gut microbiota Study Design: Factorial

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The intestinal microecology changes and metabonomics-based prognostic biomarkers screening in advanced colorectal cancer patients with qi deficiency syndrome

Project description:Interventions: Group1:Qi deficiency syndrome quantitative score>8;Group 2:Yin deficiency syndrome quantitative score>10;Group 3:deficiency syndrome quantitative score<3 with no obvious excess syndrome Primary outcome(s): serum metabonomics;Intestinal flora genome Study Design: Cohort study

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Transcriptomics reveals the molecular transcriptional regulatory network of Xinhuitong in the treatment of coronary heart disease with Qi deficiency and blood stasis syndrome

Project description:Research purpose: To explore the key targets and core signal pathways of XHT (Xinhuitong, XHT) in regulating coronary heart disease with Qi deficiency and blood stasis syndrome through transcriptomics, and reveal the transcriptional regulatory network of XHT in treating coronary heart disease with Qi deficiency and blood stasis syndrome. Research method: Using transcriptomics RNA-Seq technology, gene sequencing of myocardial tissues in the ischemic marginal zone of the Qi deficiency and blood stasis syndrome model group and the high-dose Yiqi Huoxue prescription group and searching for differential genes, from the perspective of gene regulation and expression patterns To study the possible effective drug targets and effect mechanism pathways of XHT in the treatment of coronary heart disease with Qi deficiency and blood stasis syndrome, and to further explore the treatment of coronary heart disease with Qi deficiency and blood by Chinese medicine compound prescriptions. The possible pharmacological mechanism of blood stasis syndrome, and the key molecular nodes and effect mechanism pathways suggested by it are verified by molecular biology methods.

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Integrated DIA proteomics and lipidomics analysis on non-small cell lung cancer patients with TCM syndromes

Project description:Lung cancer remains the leading cause of mortality from malignant tumors, non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases, and individualized diagnosis and treatment in traditional Chinese Medicine (TCM) is an effective trend. In this study, a proteomics research with DIA mode and a non-targeted lipidomics research were developed in NSCLC patients with Qi deficiency and Yin deficiency (QDYD) and Qi deficiency of lung-spleen (QDLS) syndromes.

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Bioinformatics analysis of transcriptome related to blood stasis syndrome in diabetes mellitus patients

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Label-free quantitative proteomic analysis of rat liver tissue

Project description:In this study, the spleen deficiency syndrome rat model was built with reserpine injection method. At first, the intervention effect of SJZD on spleen deficiency syndrome was preliminary evaluation through pharmacodynamics study. By comparing the differences proteins of liver tissues by label-free proteomics techniques, the differentially expressed proteins of spleen deficiency syndrome and SJZD intervention spleen deficiency syndrome were screened. At last, differentially expressed proteins were analyzed with bioinformatics analysis method, the potential target proteins of spleen deficiency syndrome and SJZD intervention spleen deficiency syndrome were excavated. At the same time, the corresponding metabolic pathways and biological molecular interaction network was established. We hope to probe the mechanisms of SJZD intervention spleen deficiency syndrome from the aspect of proteomic to provide a scientific basis for the clinical diagnosis and treatment of spleen deficiency syndrome.

2019-09-14 | PXD015449 |

Quantitative proteomics revealed the mechanism of Yiqi Huoxue recipe used to treat cerebral infarction with Qi deficiency and blood stasis

Project description:Huoxue Yiqi (HXYQ) recipe is widely used to treat cerebral infarction with Qi deficiency and blood stasis syndrome (CI-QDBS), but its pharmacological mechanism is still not clear. In this study, the serum samples of patients with Qi deficiency and blood stasis syndrome in the convalescent stage of cerebral infarction were used as the research object. The protein expression levels among the control group, Yiqi group and Huoxue Yiqi group were compared by non labeled quantitative proteomics technology. The difference of protein expression level was higher than 1.2 times as the significant difference. Compared with the control group, there were 120 differentially expressed proteins; Through bioinformatics analysis and biological function clustering of differentially expressed proteins, it is found that Yiqi recipe can regulate energy metabolism and nerve function and change hemorheology, while Yiqi Huoxue recipe can regulate energy metabolism, antithrombotic function and improve vascular function. This study explored the biological mechanism of Yiqi recipe and Huoxue Yiqi recipe in the protein level, which provided a molecular basis for the clinical treatment of CI-QDBS and the related research of traditional Chinese medicine.

2022-12-12 | PXD029388 |

Circulating mRNA Profiles Differ between Qi-Deficiency and Yin deficiency in Ischemic Stroke Rats with Blood Stasis Syndrome

Project description:Qi deficiency blood stasis (QDBS) and Yin deficiency blood stasis (YDBS) are the two major subtypes of which according to the traditional Chinese medicine. This study was conducted to distinguish these two syndromes at transcriptomics level and explore the underlying mechanisms.

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