Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ACBP/DBI protein neutralization for the experimental treatment of fatty liver disease

ABSTRACT: ACBP/DBI protein neutralization for the experimental treatment of fatty liver disease

PROVIDER: PRJNA1166092 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR30816743_1.fastq.gz	Fastqsanger.gz
	SRR30816743_2.fastq.gz	Fastqsanger.gz
	SRR30816744_1.fastq.gz	Fastqsanger.gz
	SRR30816744_2.fastq.gz	Fastqsanger.gz
	SRR30816745_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 60

Similar Datasets

ACBP/DBI protein neutralization for the experimental treatment of fatty liver disease

Project description:Total liver RNA extracts from adult male mice (8 weeks old, C57BL/6) subjected to Methionine and Choline Deficient Diet (regime duration: 6 weeks) and injected with monoclonal anti-ACBP/DBI (2 doses per week from week 4) were determinated to describe the therapeutic effects of neutrali-zation of ACBP/DBI to MASH-induced transcriptomic alterations.

2025-03-19 | GSE278209 | GEO

Implication of Acyl Coenzyme A Binding Protein (ACBP) in Cushing Syndrome

Project description:Acyl coenzyme A binding protein (ACBP), encoded by the diazepam binding protein (DBI) gene, plays a pivotal role in stimulating appetite and lipo-anabolic reactions, showing correlations with laboratory indications of metabolic syndrome in ostensibly healthy individuals. In a screening effort targeting inhibitors of ACBP/DBI expression among distinct neuroendocrine factors, we discovered that glucocorticoids induce ACBP/DBI secretion in cultured cells. In mouse models of iatrogenic Cushing syndrome, antibody-mediated neutralization of ACBP/DBI prevented the metabolic consequences of prolonged glucocorticoid administration. Our findings suggest that a surge in extracellular ACBP/DBI may mediate crucial aspects of Cushing syndrome.

2024-10-02 | GSE248672 | GEO

Neutralization of Acyl-CoA Binding Protein Confers Autophagy-Dependent Organ Protection

Project description:Total liver RNA extracts from adult male mice (8 weeks old, C57BL/6) injected with monoclonal anti-ACBP/DBI (1 dose per week) and subjected to Methionine and Choline Deficient Diet (regime duration: 4weeks) were analyzed to describe the effect of neutralization of ACBP/DBI to NASH-induced transcriptomic alterations.

2023-02-24 | GSE194346 | GEO

ACBP/DBI neutralization for the experimental treatment of fatty liver disease.

Project description:Acyl-CoA binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), is an extracellular checkpoint of autophagy. Here, we report that patients with histologically confirmed metabolic-associated steatohepatitis (MASH) or liver fibrosis exhibit elevated levels of circulating ACBP/DBI protein as compared to non-affected controls. Plasma ACBP/DBI strongly correlated with the NAFLD and FIB4 scores in patients, and these correlations were independent of age and body mass index. We studied the capacity of a monoclonal antibody (mAb) neutralizing mouse ACBP/DBI to combat active liver disease in several mouse models, in which steatohepatitis had been induced by four different protocols, namely, (i) methionine/choline-deficient diet, (ii) Western style diet (WD) alone, (iii) WD combined with the hepatotoxic agent CCl4, and (iv) a combination of CCl4 injections and oral ethanol challenge. Injections of anti-ACBP/DBI mAb attenuated histological, enzymological, metabolomic and transcriptomic signs of liver damage in these four models, hence halting or reducing the progression of non-alcoholic and alcoholic liver disease. Steatosis, inflammation, ballooning and fibrosis responded to ACBP/DBI inhibition at the preclinical level. Altogether, these findings support a causal role of ACBP/DBI in MASH and liver fibrosis, as well as the possibility to therapeutically target ACBP/DBI.

| S-EPMC11894144 | biostudies-literature

Acyl-coA Binding Protein neutralization improves cancer immunosurveillance

Project description:The plasma concentrations of acyl coenzyme A binding protein (ACBP, also known as diazepam-binding inhibitor, DBI, or ‘endozepine’) increase with age and obesity, two parameters that are also the most important risk factors for cancer. In mice bearing MCA205 fibrosarcoma, antibody mediated ACBP/DBI neutralization enhanced the anticancer T-cell response in the context of chemoimmunotherapy. T-cells infiltrating MCA205 tumors were sorted and submitting to single-cell TCR sequencing and single-cell RNA sequencing (scRNAseq) to identify the mechanisms driving this improvement.

2024-09-11 | GSE242119 | GEO

Knockout of the Acyl CoA binding protein (ACBP) in mice - expression profile from the liver of 21 days old ACBP-/- and +/+ mice.

Project description:The ACBP knockout were created by targeted disruption of the gene in mice. The expression profiling was performed on liver tissue from ACBP-/- (KO) and +/+ (WT) mice at the age of 21 days, which in our study is the time immediately before weaning. The mice used for this experiment were taken directly away from their mother. Thus, having free access to chow and breast milk until sacrificed at 8-11am 15 ACBP-/- and 15 +/+ control mice divided into 6 groups (KO1, KO2, KO3, WT1, WT2 and WT3) with 5 individuals in each group were used for this study.

2010-11-26 | E-GEOD-24451 | biostudies-arrayexpress

Supplementation of ACBP/DBI for the Experimental Treatment of Anorexia Nervosa

Project description:Total liver RNA extracts from adult female mice (8-week-old) subjected to CRS (chronic restraint stress) or CDDP (cisplatin) induced anorexia with or without ACBP/DBI delivery to investigate the impact of ACBP/DBI on anorexia-induced transcriptomic alterations.

2024-07-12 | GSE237766 | GEO

Knockout of the Acyl CoA binding protein (ACBP) in mice - expression profile from the liver of 21 days old ACBP-/- and +/+ mice.

2010-11-26 | GSE24451 | GEO

Bulk RNA seq data from mice lacking ACBP in brown and white adipose tissue

Project description:The experimental aim was to examine transcriptional changes in brown and white adipose tissue isolated from Adipoq-Acbp-/- housed at RT and brown adipose tissue isolated from Ucp1-Acbp-/- mice housed at room temperature.

2025-03-09 | E-MTAB-14881 | biostudies-arrayexpress

Supplementation of ACBP/DBI for the Experimental Treatment of Anorexia Nervosa

Project description:Supplementation of ACBP/DBI for the Experimental Treatment of Anorexia Nervosa

| PRJNA996577 | ENA