Project description:Overwintering mortality is the greatest threat to the supply of healthy bee colonies available for pollination of spring-blooming crops, but efforts to mitigate colony losses are hindered because underlying mechanisms remain poorly understood. In the present study, we identified that sirtuin signaling pathway is the most significantly affected pathway in collapsing overwintering colonies that carried a high prevalence of pathogens and is a convergent signaling hub that links mitochondrial dysfunction and metabolism alterations. We showed that the expression of SIRT1, a major sirtuin regulating energy and immune metabolism, was significantly downregulated in diseased overwintering bees and bees exposed to cold challenge alone. We demonstrated that activation of SIRT1 expression by SRT1720, a SIRT1 activator, could result in increased robustness and lifespan extension of cold-stressed bees. The novel information gained from this study provides a promising avenue for the development of therapeutic strategies for mitigating colony losses, both overwinter and annually.

2022-12-29 | GSE196998 | GEO

Trancriptome analysis of honey bees (Apis mellifera) infected with Nosema ceranae

Project description:The microsporidia Nosema ceranae are intracellular parasites that proliferate in the midgut epithelial cells of honey bees (Apis mellifera). To analyze the pathological effects of those microsporidia, we orally infected honey bee workers 7 days after their emergence. Bees were flash frozen 15 days after the infection. Then, the effects on the gut ventriculi were analyzed and compared to non-infected (control) bees.

2012-05-23 | GSE25455 | GEO

Trancriptome analysis of honey bees (Apis mellifera) infected with Nosema ceranae

2011-08-31 | E-GEOD-25455 | biostudies-arrayexpress

Antennae transcriptomics of Varroa-hygienic and Nurse/Forager bees

Project description:The Varroa mite represents the main threat of honey bees (Apis mellifera). Bees from some colonies can limit the proliferation of this parasite by detecting and removing parasitized brood, such behavior is defined as Varroa sensitive Hygiene (VSH). This is an important issue for selecting colonies that can survive Varroa outbreaks. We therefore study the molecular meachnisms underlying this behavior by comparing the antennae transcriptomic profile of VSH and non-VSH bees. Those profiles were further compared to to the profiles of nurses and forager profiles involved in brood care and food collection, respectively.

2017-02-09 | GSE63613 | GEO

Combined transcriptome and miRNA-based analysis of the molecular mechanism of collection preference in Italian honey bees

Project description:A combined transcriptomic and miRNA-based analysis of the molecular mechanism of collection preference in Italian honey bees was conducted, mainly selecting the long-range sensor tentacles and the proximal sensor mouthparts.

2024-04-22 | GSE230384 | GEO

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