Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Spatial Transcriptomics of IPMN Reveals Divergent Indolent and Malignant Progenitor Phenotypes

ABSTRACT: Spatial Transcriptomics of IPMN Reveals Divergent Indolent and Malignant Progenitor Phenotypes

PROVIDER: PRJNA1168172 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Spatial Transcriptomics of IPMN Reveals Divergent Indolent and Malignant Progenitor Phenotypes

Project description:Spatial analysis of intraductal papillary mucinous neoplasms identifies a high-risk molecular subtype that associates with basal-like PDAC.

2025-01-06 | GSE278670 | GEO

Transcriptome analysis of Arid1a-deficient IPMN and Brg1-deficient IPMN

Project description:Mutations of subunit genes of the SWI/SNF chromatin remodeling complexes were found in 12-23% of human Pancreatic Ductal Adenocarcinoma (PDAC). We previously showed that Brg1, a catalytic ATPase subunit of the SWI/SNF chromatin remodeling complexes, inhibits the formation of intraductal pancreatic mucinous neoplasms (IPMN) and IPMN-derived PDAC from ductal cells. On the other hand, ARID1A is the most frequent target of mutations in the SWI/SNF chromatin remodeling complexes in human PDAC. We found that Arid1a loss in the context of mutant Kras resulted in formation of IPMN and PDAC. We also found that the incidence of PDAC formation in Ptf1a-Cre; KrasG12D; Arid1af/f mice was markedly lower than that in Ptf1a-Cre; KrasG12D; Brg1f/f mice despite the similarities between Arid1a-deficient and Brg1-deficient IPMNs. We extracted total RNA from intraductal papillary mucinous neoplasms (IPMNs) in Ptf1a-Cre; KrasG12D; Arid1af/f and Ptf1a-Cre; KrasG12D; Brg1f/f mice and perform microarray analysis.

2018-03-31 | GSE96926 | GEO

Visium Spatial Transcriptomics expression profiles from IPMN samples of the pancreas

Project description:Intraductal Papillary Mucinous Neoplasms (IPMN) are pancreatic mucinous cysts that can progress to cancer. We used spatial transcriptomics to characterize the epithelium and microenvironment of IPMN samples of different grades and histological subtypes.

2023-06-07 | GSE233293 | GEO

Visium Spatial Transcriptomics of a murine model of IPMN

Project description:Pancreata were collected from two Kras;Gnas mice and analyzed by Visium Spatial Gene Expression to evaluate the transcriptional profile associated with NKX6-2 that was observed in the human IPMN samples.

2023-06-07 | GSE233317 | GEO

Differential gene expression in the liver among crossbred beef steers with divergent gain and feed intake phenotypes

Project description:Steer liver transcriptome Evaluation of the naturally occurring transcriptome variation in liver among beef steers with divergent gain and feed intake phenotypes.

2016-03-31 | GSE75700 | GEO

Differential gene expression in the spleen among crossbred beef steers with divergent gain and feed intake phenotypes.

Project description:Steer spleen transcriptome Evaluation of the naturally occurring transcriptome variation in the spleen among beef steers with divergent gain and feed intake phenotypes.

2015-10-30 | GSE73261 | GEO

Differential gene expression in the mesenteric fat among crossbred beef steers with divergent gain and feed intake phenotypes

Project description:Steer mesenteric fat transcriptome. Evaluation of the naturally occurring transcriptome variation in mesenteric fat among beef steers with divergent gain and feed intake phenotypes.

2015-11-30 | GSE73699 | GEO

ILyAD (Indolent Lymphoma And vitamin D)

Project description:ILyAD (Indolent Lymphoma And vitamin D)

| PRJNA1055198 | ENA

ILyAD (Indolent Lymphoma And vitamin D)

Project description:ILyAD (Indolent Lymphoma And vitamin D)

| PRJNA1055197 | ENA

Differential gene expression in the duodenum, jejunum, and ileum among crossbred beef steers with divergent gain and feed intake phenotypes.

Project description:Steer small intestine transcriptome Evaluation of the naturally occurring transcriptome variation among beef steers with divergent gain and feed intake phenotypes.

2015-09-19 | GSE73159 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data