Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Visium Spatial Transcriptomics of the Human Hypothalamus

ABSTRACT: Visium Spatial Transcriptomics of the Human Hypothalamus

PROVIDER: PRJNA1169024 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR30889184_1.fastq.gz	Fastqsanger.gz
	SRR30889184_2.fastq.gz	Fastqsanger.gz
	SRR30889185_1.fastq.gz	Fastqsanger.gz
	SRR30889185_2.fastq.gz	Fastqsanger.gz
	SRR30889186_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

Visium Spatial Transcriptomics of the Human Hypothalamus

Project description:The hypothalamus is a brain region that plays a key role in coordinating fundamental biological functions. However, our understanding of the underlying cellular components and neurocircuitries have, until recently, emerged primarily from rodent studies. Here, we combine single-nucleus sequencing of 433,369 human hypothalamic cells with spatial transcriptomics, generating a comprehensive spatio-cellular transcriptional map of the hypothalamus, the ‘HYPOMAP’. Whilst conservation of neuronal cell types between humans and mice, based on transcriptomic identity, is generally high, there are notable exceptions. Specifically, there are significant disparities in the identity of POMC neurons and in the expression levels of GPCRs between the two species that carry direct implications for currently approved obesity treatments. Out of the 452 hypothalamic cell types, we find 291 neuronal clusters are significantly enriched for expression of BMI GWAS genes. This enrichment is driven by 426 ‘effector’ genes. Rare deleterious variants in 6 of these, MC4R, PCSK1, POMC, CALCR, BSN and CORO1A, associate with BMI at population level, and CORO1A has not previously been linked to BMI. Thus, HYPOMAP provides a detailed atlas of the human hypothalamus in a spatial context and serves as an important resource to identify novel druggable targets for treating a wide range of conditions, including reproductive, circadian, and metabolic disorders.

2025-01-29 | GSE278848 | GEO

Visium Spatial transcriptomics analysis of human primary colorectal cancer

Project description:To reveal the spatial distribution and the difference gene expression pattern of cancer cells in colorectal cancer, Visium spatial transcriptomics of four CRC patients was applied

2023-03-14 | GSE226997 | GEO

Spatial transcriptomics of gastric cancers (Visium 10X platform)

Project description:A total of 9 primary gastric cancers (1 pair of primary-metastasis, GC6) analyzed using Visium 10X platform-based spatial transcriptomics.

2023-12-26 | GSE251950 | GEO

Spatial Transcriptomics of the human musculotendinous unit, the myotendinous junction

Project description:Identification of cell types in the interphase between muscle and tendon by Visium Spatial Transcriptomics of four human semitendinous muscle-tendon biopsies. Cell types identified by single nuclei RNA seq on similar tissue were localized in situ with the use of Spatial Transcriptomics.

2023-03-02 | E-MTAB-12530 | biostudies-arrayexpress

Spatial transcriptomics (Visium, 10x Genomics) data of Duchenne mouse models

Project description:Quadricep sections of 10µm thick were placed on Visium spatial transcriptomics slide to obtain spatial datasets for these skeletal muscle sections

2023-06-28 | GSE199659 | GEO

Visium Spatial transcriptomics analysis of human primary colorectal cancer

Project description:Visium Spatial transcriptomics analysis of human primary colorectal cancer

| PRJNA942633 | ENA

Spatial transcriptomics of the axolotl forebrain

Project description:To investigate spatial heterogeneities in the axolotl forebrain, a coronal section of it was obtained for spatial transcriptomics using Visium V1.

2022-07-20 | E-MTAB-11665 | biostudies-arrayexpress

Spatial transcriptomics (Visium) of first and second-trimester human gonads

Project description:Spatial transcriptomics (Visium) of first and second-trimester human gonads

| PRJEB54898 | ENA

Spatial transcriptomics of human implantation sites, placenta and decidua

Project description:These samples are part of a study to provide a spatially resolved single-cell multiomics map of human trophoblast differentiation in early pregnancy. Here we profiled with 10x Visium Spatial transcriptomics of the entire maternal-fetal interface including the myometrium, allowing us to resolve the full trajectory of trophoblast differentiation.

2023-02-03 | E-MTAB-12698 | biostudies-arrayexpress

Spatial transcriptomics of human colorectal cancer liver metastatic samples

Project description:These samples are part of a study investigating cancer cell plasticity in colorectal cancer metastasis. Spatial transcriptomics was performed using 10x Genomics Visium on colorectal cancer liver metastatic patient samples.

2025-04-22 | E-MTAB-13655 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data