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TNF Drives Aberrant BMP Signaling to Induce Endothelial and Mesenchymal Dysregulation in a Transgenic Model of Pulmonary Hypertension

ABSTRACT: TNF Drives Aberrant BMP Signaling to Induce Endothelial and Mesenchymal Dysregulation in a Transgenic Model of Pulmonary Hypertension

PROVIDER: PRJNA1171470 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30946867.fastq.gz	Fastqsanger.gz
	SRR30946868.fastq.gz	Fastqsanger.gz
	SRR30946869.fastq.gz	Fastqsanger.gz
	SRR30946870.fastq.gz	Fastqsanger.gz
	SRR30946871.fastq.gz	Fastqsanger.gz

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TNF Drives Aberrant BMP Signaling to Induce Endothelial and Mesenchymal Dysregulation in a Transgenic Model of Pulmonary Hypertension

Project description:The pathobiology of pulmonary hypertension (PH) is complex and multiple cell types (endothelial, smooth muscle, fibroblast, pericyte) contribute to disease pathogenesis. However, the specific molecular crosstalk between endothelial and mesenchymal cells to promote PH is poorly characterized. We previously demonstrated that tumor necrosis factor alpha transgenic (TNF-Tg) mice have a severe PH phenotype.

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