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Rattus norvegicus breed:Sprague Dawley Rat

ABSTRACT: Transcriptional profile of placentae from Ad Flt1-induced PE model rats and their controls on gestational day 13

PROVIDER: PRJNA1173398 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31035717_1.fastq.gz	Fastqsanger.gz
	SRR31035717_2.fastq.gz	Fastqsanger.gz
	SRR31035718_1.fastq.gz	Fastqsanger.gz
	SRR31035718_2.fastq.gz	Fastqsanger.gz
	SRR31035719_1.fastq.gz	Fastqsanger.gz

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Polyorchidism in a young Sprague-Dawley rat.

Project description:Duplicate testes lined in series were observed in the right scrotum of a 6-week-old Sprague-Dawley rat in a single-dose toxicity study. Of the two right testicles, one was spherical and less than half the size of a normal testis. The other was oval-shaped, slightly smaller than a normal testis, and possessed clear, tortuous blood vessels similar to those of a normal testis. Each right testis was grossly separated but faced the intertesticular adipose tissue and was sparsely joined by thin cord-like structures. Only one epididymis covered or encompassed the two right testes. The caput epididymis was attached to the smaller spherical testis, whereas the cauda epididymis was attached to the oval testis. Histopathological examination revealed that the smaller spherical testis on the right side and the testis on the left side were normal. The oval-shaped testis on the right exhibited markedly dilated degenerative seminiferous tubules with one to two layers of Sertoli or germ cells, and almost no spermatogenesis was observed. Multinucleated germ cells were observed in the lumen of the degenerated seminiferous tubules. The right epididymis was morphologically normal and contained few sperm in the epididymal duct of the tail. The cord-like structures between duplicate testes comprised fibrous and adipose tissues. Single efferent ductules, ectopic cartilage, and skeletal muscle tissues were buried in the adipose tissue. To our knowledge, this is the first report of spontaneous polyorchidism in a rodent.

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Rattus norvegicus strain:Sprague Dawley | isolate:Brain Bits USA | cultivar:Rat

Project description:Rattus norvegicus Transcriptome Male 1 Embryonic day 13

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Rattus norvegicus strain:Sprague Dawley | isolate:Brain Bits USA | cultivar:Rat

Project description:Rattus norvegicus Transcriptome Male 2 Embryonic day 13

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Rattus norvegicus strain:Sprague Dawley | isolate:Brain Bits USA | cultivar:Rat

Project description:Rattus norvegicus Transcriptome Male 3 Embryonic day 13

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Rattus norvegicus strain:Sprague Dawley | isolate:Brain Bits USA | cultivar:Rat

Project description:Rattus norvegicus Transcriptome Female 1 Embryonic day 13

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Project description:Rattus norvegicus Transcriptome Female 3 Embryonic day 13

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A gene catalogue of the Sprague-Dawley rat gut metagenome.

Project description:Laboratory rats such as the Sprague-Dawley (SD) rats are an important model for biomedical studies in relation to human physiological or pathogenic processes. Here we report the first catalog of microbial genes in fecal samples from Sprague-Dawley rats. The catalog was established using 98 fecal samples from 49 SD rats, divided in 7 experimental groups, and collected at different time points 30 days apart. The established gene catalog comprises 5,130,167 non-redundant genes with an average length of 750 bp, among which 64.6% and 26.7% were annotated to phylum and genus levels, respectively. Functionally, 53.1%, 21.8%,and 31% of the genes could be annotated to KEGG orthologous groups, modules, and pathways, respectively. A comparison of rat gut metagenome catalogue with human or mouse revealed a higher pairwise overlap between rats and humans (2.47%) than between mice and humans (1.19%) at the gene level. Ninety-seven percent of the functional pathways in the human catalog were present in the rat catalogue, underscoring the potential use of rats for biomedical research.

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Adult Sprague-Dawley Rat intestinal epithelium

Project description:The proximal small intestine of humans and rats contain a distinct cell type not represented in mouse intestine. We used scRNA-seq to analyze the transcriptional profile of CFTR High Expressers (CHEs) from adult male Sprague Dawley rat jejunal epithelium compared to other cells that arise from the secretory lineage.

2025-03-10 | GSE272055 | GEO

Edible Bird's Nest Supplementation Improves Male Reproductive Parameters of Sprague Dawley Rat.

Project description:Edible bird's nest (EBN) is reported to have a positive in vitro proliferative effect and contain male reproductive hormones. Spermatogonia cells proliferate during spermatogenesis under male reproductive hormones stimulation that include testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). Characterization of EBN through liquid chromatography-mass spectrometry (LCMS) has found testosterone as a base peak. Six types of amino acids, estradiol and sialic acid were among the major peaks that have been characterized. Based on the presence of these reproductive components, this study evaluated different doses of EBN on sperm parameters and male reproductive hormones of Sprague Dawley rats. Sixteen Sprague Dawley rats at the age of eight weeks were randomly and equally divided into four groups, which are Control, 10 mg/kg BW/d 50 mg/kg BW/d, and 250 mg/kg BW/d EBN group. The rats were fed with EBN enriched pellet daily and water ad-libitum. Rats were sacrificed and the organ was weighed for organ coefficients after eight weeks of treatment. Sperm concentration, percentage of sperm motility, and sperm viability were evaluated. Meanwhile, ELISA method was used to measure testosterone, FSH, and LH. Findings showed that there were no significant differences in organ coefficient between groups. Supplementation of 250 mg/kg BW/d EBN demonstrated a significant increase in sperm concentration, percentage of sperm motility as well as FSH and LH level compared to 10 mg/kg BW/d group. There was a dose-dependent increase in testosterone level but was not significant between groups. Based on these findings, EBN is concluded to have crucial effects on male reproductive parameters.

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Mineralization of articular cartilage in the Sprague-Dawley rat: characterization and mechanical analysis.

Project description: Not available

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