Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Investigation of genes involoved in Corydalis incisa (Thunb.) Pers. (CIP)-induced differentiation in acute myeloid leukemia (AML).

ABSTRACT: Investigation of genes involoved in Corydalis incisa (Thunb.) Pers. (CIP)-induced differentiation in acute myeloid leukemia (AML).

PROVIDER: PRJNA1178566 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31134635.fastq.gz	Fastqsanger.gz
	SRR31134636.fastq.gz	Fastqsanger.gz
	SRR31134637.fastq.gz	Fastqsanger.gz
	SRR31134638.fastq.gz	Fastqsanger.gz
	SRR31134639.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Investigation of genes involoved in Corydalis incisa (Thunb.) Pers. (CIP)-induced differentiation in acute myeloid leukemia (AML).

Project description:Acute myeloid leukemia (AML) is the most common form of leukemia in adults. Differentiation therapy targets the key pathologic features of AML, the blockade of differentiation in myeloid progenitor cells. This study screened 100 plant extracts native to South Korea to search for those with differentiation-inducing activity in AML. Of these, Corydalis incisa (Thunb.) Pers. (CIP) exhibited the highest efficacy.CIP induced myeloid differentiation, decreased cell viability, increased cell apoptosis, and cell cycle arrest in multiple AML cell lines. We performed Quantseq 3' mRNA seqencing to understand CIP-induced differentiation and identify potential targets of CIP using CIP-resistant cell line.

2025-02-26 | GSE280425 | GEO

Project description:The complete chloroplast genome sequence of Corydalis pallida (Thunb.) Pers

| PRJNA1081936 | ENA

Trapa incisa

Project description:Trapa incisa overview

| PRJNA765099 | ENA

Lobosphaera incisa

Project description:Lobosphaera incisa overview

| PRJNA266024 | ENA

Trapa incisa

Project description:Trapa incisa Assembly

| PRJNA770819 | ENA

Trapa incisa

Project description:Trapa incisa Assembly

| PRJNA770811 | ENA

p/CIP gene regulation in mouse embryonic stem cells

Project description:p/CIP binds to many nuclear receptors and plays a major role in hormone dependent transcription of genes. Recently, p/CIP was shown to affect mouse stem cell pluripotency. Microarray gene expression analysis was conducted to assess the role of p/CIP in mouse embryonic stem cells.

2013-08-21 | GSE50017 | GEO

Lobosphaera incisa

Project description:Lobosphaera incisa Genome sequencing

| PRJNA262782 | ENA

CIP, a cardioprotective factor, inhibits the transition from cardiac hypertrophy to heart failure

Project description:Heart failure is characterized by the inability of the heart to pump effectively and generate proper blood circulation to meet the body's needs; it is a devastating condition that affects more than 100 million people globally. In spite of this, little is known about the mechanisms regulating the transition from cardiac hypertrophy to heart failure. Previously, we identified a cardiomyocyte-enriched gene, CIP, which regulates cardiac homeostasis under pathological stimulation. Here, we show that the cardiac transcriptional factor GATA4 binds the promotor of CIP gene and regulates its expression. We further determined that both CIP mRNA and protein decrease in diseased human hearts. In a mouse model, induced cardiac-specific overexpression of CIP after the establishment of cardiac hypertrophy protects the heart by inhibiting disease progression toward heart failure. Transcriptome analyses revealed that the IGF, mTORC2 and TGFβ signaling pathways mediate the inhibitory function of CIP on pathologic cardiac remodeling. Our study demonstrates GATA4 as an upstream regulator of CIP gene expression in cardiomyocytes, as well as the clinical significance of CIP expression in human heart disease. More importantly, our investigation suggests CIP is a key regulator of the transition from cardiac hypertrophy to heart failure. The ability of CIP to intervene in the onset of heart failure suggests a novel therapeutic avenue of investigation forthe prevention of heart disease progression.

2022-03-05 | GSE194149 | GEO

Trapa incisa

Project description:Trapa incisa Genome sequencing and assembly

| PRJNA726367 | ENA