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Effects of Trem2 depletion on gene expressions in a mouse photothrombotic stroke model

ABSTRACT: Effects of Trem2 depletion on gene expressions in a mouse photothrombotic stroke model

PROVIDER: PRJNA1180902 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31190337_1.fastq.gz	Fastqsanger.gz
	SRR31190337_2.fastq.gz	Fastqsanger.gz
	SRR31190338_1.fastq.gz	Fastqsanger.gz
	SRR31190338_2.fastq.gz	Fastqsanger.gz
	SRR31190339_1.fastq.gz	Fastqsanger.gz

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Effects of Trem2 depletion on gene expressions in a mouse photothrombotic stroke model

Project description:Ischemic stroke is a major threat to public health. Microglia-mediated neuroinflammation is a double-edged sword for neuronal survival after stroke. Triggering receptor expressed on myeloid cells 2 (Trem2) is specifically expressed on the surface of myeloid cell, including microglia. Here, we applied a photothrombotic mouse model of stroke to better understand the role of Trem2 in post-stroke neuroinflammation. In this model, Trem2 was sufficiently induced with sustainably elevated inflammatory responses. Our results demonstrated that Trem2-depletion can ameliorate ischemic injury with enhanced neuronal survival, reduced pro-inflammatory cytokine levels, and improved neurological functions. Our results suggested that Trem2 depletion is neuroprotective during ischemic stroke.

2024-12-29 | GSE280846 | GEO

Transcriptomic and proteomic multi-model global gene expression analysis reveals regulatory signatures during ischemia stroke (photothrombotic internal ischemia stroke)

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Gene expression profiles of cerebral cortice from sham- and X-ray-irradiated mice after photothrombotic strokes

Project description:Current study aims to study the gene expression change after photothrombotic strokes, and the potential beneficial effects of whole-body X-ray irradiation on stroke mice

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Project description:The effect of RVG-SCMH1-Evs treatment on photothrombotic (PT) stroke mice

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Photothrombotic Cerebral Stroke as a Model of Post-Stroke Seizures/Epilepsy in aged mice

Project description:Stroke is a prevalent disorder representing the third leading cause of death and major cause of disability. Post-stroke epilepsy (PSE) has been recognized as a common clinical issue after stroke, accounting for 30-40% of the causes of epilepsy among older adults. In this study, we determined GABAA receptor-mediated seizure susceptibility after PT cerebral stroke in aged mice. Young adult mice around 10 weeks of age are widely used in stroke experiments. However, as most strokes are diagnosed in the elderly and PSE has been recognized as a common clinical incidence after stroke, we utilized photothrombosis (PT) model of cerebral ischemia and examined seizure susceptibility and brain injury using combined behavioral (video) and EEG monitoring and histological (MRI) assessments. To investigate GABAA receptor-mediated convulsive/non-convulsive seizures, lower-doses of pentylenetetrazol (PTZ) was injected. PTZ susceptibility in aging mice increased compared to young adults. One month after PT stroke, aged PT stroke mice exhibited severe convulsive seizures (late-onset). These findings exhibited the increase of GABAA receptor-mediated seizures susceptibility in PT stroke aging mice, but not in young adults.

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Transcriptomic and proteomic multi-model global gene expression analysis reveals regulatory signatures during ischemia stroke (photothrombotic internal ischemia stroke)

Project description:Transcriptomic and proteomic multi-model global gene expression analysis reveals regulatory signatures during ischemia stroke (photothrombotic internal ischemia stroke)

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Transcriptomic and proteomic multi-model global gene expression analysis reveals regulatory signatures during ischemia stroke (photothrombotic cerebral ischemia stroke)

Project description:Transcriptomic and proteomic multi-model global gene expression analysis reveals regulatory signatures during ischemia stroke (photothrombotic cerebral ischemia stroke)

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