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Gene expression profiling of cellular senescence in mouse articular chondrocytes

ABSTRACT: Gene expression profiling of cellular senescence in mouse articular chondrocytes

PROVIDER: PRJNA1181838 | ENA |

REPOSITORIES: ENA

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Gene expression profiling of cellular senescence in mouse articular chondrocytes

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RNA-seq data from mouse articular chondrocytes

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MYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling

Project description:As the unique cell type in articular cartilage, chondrocyte senescence is a crucial cellular event contributing to osteoarthritis development. Here we show that clathrin-mediated endocytosis and activation of Notch signaling promotes chondrocyte senescence and osteoarthritis development, which is negatively regulated by myosin light chain 3. Myosin light chain 3 (MYL3) protein levels decline sharply in senescent chondrocytes of cartilages from model mice and osteoarthritis (OA) patients. Conditional deletion of Myl3 in chondrocytes significantly promoted, whereas intra-articular injection of adeno-associated virus overexpressing MYL3 delayed, OA progression in male mice. MYL3 deficiency led to enhanced clathrin-mediated endocytosis by promoting the interaction between myosin VI and clathrin, further inducing the internalization of Notch and resulting in activation of Notch signaling in chondrocytes. Pharmacologic blockade of clathrin-mediated endocytosis-Notch signaling prevented MYL3 loss-induced chondrocyte senescence and alleviated OA progression in mice. Our results establish a previously unknown mechanism essential for cellular senescence and provide a potential therapeutic direction for OA.

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ActivinA effect on mouse articular chondrocytes

Project description:ActivinA effect on mouse articular chondrocytes

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Nox4 effect on mouse articular chondrocytes

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Nox4 effect on mouse articular chondrocytes

Project description:Gene expression profiling of mouse articular chondrocytes infected with Ad-C or Ad-Nox4 In this study, we have attempted to explore the effects of Nox4 and have identified numerous genes which are involved in osteoarthritis pathogenesis.

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Project description:Gene expression profiling of mouse articular chondrocytes infected with Ad-C or Ad-Rip3 In this study, we have attempted to explore the effects of Rip3 and have identified numerous genes which are involved in osteoarthritis pathogenesis.

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Genes regulated by TGF-beta in bovine articular chondrocytes

Project description:Bovine articular chondrocytes were grown in micromass culture and were either untreated or treated with 5 ng TGF-b1/ml for 8 hours to identify genes regulated by TGF-b. Six total samples were analyzed. Three biological replicates of untreated bovine articular chondrocytes grown in micromass culture and three biological replicates of bovine articular chondrocytes grown in micromass culture and treated with 5ng TGF-b1/ ml for 8 hours.

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