Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Decoding the chemical language of RiPPs from the untapped Archaea domain

ABSTRACT: Decoding the chemical language of RiPPs from the untapped Archaea domain

PROVIDER: PRJNA1181845 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31219827_1.fastq.gz	Fastqsanger.gz
	SRR31219827_2.fastq.gz	Fastqsanger.gz
	SRR31219828_1.fastq.gz	Fastqsanger.gz
	SRR31219828_2.fastq.gz	Fastqsanger.gz
	SRR31219829_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Decoding the chemical language of RiPPs from the untapped Archaea domain

Project description:Chemical communication is crucial in ecosystems with complex microbial assemblages. However, due to archaeal cultivation challenges, our understanding of the structure diversity and function of secondary metabolites (SMs) within archaeal communities is limited compared to the extensively studied and well-documented bacterial counterparts. Our comprehensive investigation into the biosynthetic potential of archaea, combined with metabolic analyses and the first report of heterologous expression in archaea, has unveiled the previously unexplored biosynthetic capabilities and chemical diversity of archaeal ribosomally synthesized and post-translationally modified peptide (RiPP). We have identified twenty-four new lanthipeptides of RiPPs exhibiting unique chemical characteristics, including a novel subfamily featuring an unexplored type with diamino-dicarboxylic (DADC) termini, largely expanding the chemical landscape of archaeal SMs. This sheds light on the chemical novelty of archaeal metabolites and emphasizes their potential as an untapped resource for natural product discovery. Additionally, archaeal lanthipeptides demonstrate specific antagonistic activity against haloarchaea, mediating the unique biotic interaction in the halophilic niche. Furthermore, they showcased a unique ecological role in enhancing the host's motility by inducing the rod-shaped cell morphology and upregulating the archaellum gene flgA1, facilitating the archaeal interaction with abiotic environments. These discoveries broaden our understanding of archaeal chemical language and provide promising prospects for future exploration of SM-mediated interaction.

2024-11-09 | GSE281021 | GEO

Leukocyte gene regulation and patterns of natural language use.

Project description:Analysis of transcript abundance estimates as a function of demographic, psychometric, and language use features.

2017-12-05 | GSE87656 | GEO

Decoding the chemical language of Suillus fungi: genome mining and untargeted metabolomics uncover terpene chemical diversity

Project description:This research highlights the importance of combining genomics and metabolomics to advance our understanding of the chemical diversity underpinning fungal signaling and communication.

2024-02-13 | MSV000094072 | MassIVE

Right-brain expression-biased wnt3 is vital in maintaining normal language function via combined functional genomic and genetic analysis

Project description:Language is a unique human capability with limited molecular understanding due to the lack of animal models and technical constraints. Transcriptomics analysis offers a comprehensive view of gene expression in specific tissues, aiding the understanding of their functions. However, such patterns have been underexplored in language-related regions of the human brain. This study conducts a comprehensive transcriptomic analysis of 125 samples from 13 language-related Brodmann areas (BAs) in both hemispheres of five human postmortem brains. The expression landscape of human language-related regions is mapped, revealing higher expression in the right hemisphere, notably BA45 (Broca’s area) and BA3/1/2 (ventral sensory-motor cortex). Integrative analysis of differentially expressed genes and language-relevant genetic discoveries provides insights into the rs62060948 locus. The findings suggest that the rs62060948-MYC-WNT3 axis plays a crucial role in language function in BA44 of the right hemisphere. Behavior tests in mice show that Wnt3 knockdown in the right auditory cortex leads to abnormal behaviors, confirming that imbalanced Wnt3 expression impacts language function. Pathway analysis indicates that Wnt3 maintains nervous system development through neuron ensheathment. This study enhances understanding of the molecular mechanisms underlying human language function and identifies potential targets for language disorder therapies.

2025-01-29 | GSE287961 | GEO

Volga-Oka language shift

Project description:Genetic admixture and language shift in the medieval Volga-Oka interfluve

| PRJEB57974 | ENA

Atmospheric hydrogen oxidation extends to the domain archaea

Project description:Diverse aerobic bacteria use atmospheric hydrogen (H2) and carbon monoxide (CO) as energy sources to support growth and survival. Though recently discovered, trace gas oxidation is now recognised as a globally significant process that serves as the main sink in the biogeochemical H2 cycle and sustains microbial biodiversity in oligotrophic ecosystems. While trace gas oxidation has been reported in nine phyla of bacteria, it was not known whether archaea also use atmospheric H2. Here we show that a thermoacidophilic archaeon, Acidianus brierleyi (Thermoproteota), constitutively consumes H2 and CO to sub-atmospheric levels. Oxidation occurred during both growth and survival across a wide range of temperatures (10 to 70°C). Genomic analysis demonstrated that A. brierleyi encodes a canonical carbon monoxide dehydrogenase and, unexpectedly, four distinct [NiFe]-hydrogenases from subgroups not known to mediate aerobic H2 uptake. Quantitative proteomic analyses showed that A. brierleyi differentially produced these enzymes in response to electron donor and acceptor availability. A previously unidentified group 1 [NiFe]-hydrogenase, with a unique genetic arrangement, is constitutively expressed and upregulated during stationary phase and aerobic hydrogenotrophic growth. Another archaeon, Metallosphaera sedula, was also found to oxidize atmospheric H2. These results suggest that trace gas oxidation is a common trait of aerobic archaea, which likely plays a role in their survival and niche expansion, including during dispersal through temperate environments. These findings also demonstrate that atmospheric H2 consumption is a cross-domain phenomenon, suggesting an ancient origin of this trait, and identify previously unknown microbial and enzymatic sinks of atmospheric H2 and CO.

2024-02-26 | PXD040286 | Pride

Decoding murine cytomegalovirus

Project description:Decoding murine cytomegalovirus

| PRJNA874807 | ENA

archaea

Project description:archaea Raw sequence reads

| PRJNA616166 | ENA

archaea

Project description:archaea Raw sequence reads

| PRJNA495889 | ENA

Archaea

Project description:archaea Raw sequence reads