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Revealing the Immune Response of Sitona callosus to Beauveria bassiana Infection through Integrative Analyses of Transcriptomics and Metabolomics

ABSTRACT: Revealing the Immune Response of Sitona callosus to Beauveria bassiana Infection through Integrative Analyses of Transcriptomics and Metabolomics

PROVIDER: PRJNA1182291 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31229908_1.fastq.gz	Fastqsanger.gz
	SRR31229908_2.fastq.gz	Fastqsanger.gz
	SRR31229909_1.fastq.gz	Fastqsanger.gz
	SRR31229909_2.fastq.gz	Fastqsanger.gz
	SRR31229910_1.fastq.gz	Fastqsanger.gz

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Revealing the Immune Response of Sitona callosus to Beauveria bassiana Infection through Integrative Analyses of Transcriptomics and Metabolomics

Project description:The legume pest Sitona callosus poses a significant threat to alfalfa growth. Due to its unique life cycle, Beauveria bassiana has emerged as an effective fungus for controlling S. callosus . We conducted a comprehensive analysis of the transcriptome and metabolome of S. callosus infected by B. bassiana. Differential expression of antifungal genes, including heat shock genes, cytochrome P450 (CYP450) genes, cathepsin proteases, and C-type lectin were identified in S. callosus. Pathway analysis revealed associations between immune genes and metabolites involved in autophagy-animal, glucagon signaling pathway, and glycerophospholipid metabolism. These findings provide valuable insights for enhancing the control efficacy of Beauveria bassiana on Sitona callosus.

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