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Alteration in mRNA expression in hippocampus and next-generation effects due to paternal exposure to the neonicotinoid pesticide clothianidin

ABSTRACT: Alteration in mRNA expression in hippocampus and next-generation effects due to paternal exposure to the neonicotinoid pesticide clothianidin

PROVIDER: PRJNA1183312 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31278027_1.fastq.gz	Fastqsanger.gz
	SRR31278027_2.fastq.gz	Fastqsanger.gz
	SRR31278028_1.fastq.gz	Fastqsanger.gz
	SRR31278028_2.fastq.gz	Fastqsanger.gz
	SRR31278029_1.fastq.gz	Fastqsanger.gz

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Alteration in mRNA expression in hippocampus and next-generation effects due to paternal exposure to the neonicotinoid pesticide clothianidin

Project description:Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides, which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.The main purpose of this study was to estimate the neurobehavioral effects on offspring mice resulting from paternal exposure to the neonicotinoid pesticide clothianidin (CLO).Hippocampal RNA sequence data revealed that paternal CLO exposure altered the expression of genes related to the nervous system in male offspring, affecting pathways such as axonal guidance signaling, synaptogenesis signaling pathway, and calcium signaling.

2024-11-07 | GSE281282 | GEO

Acute effects of NOAEL-dose of neonicotinoid clothianidin on the gene expression profiles in cerebellum of male mice

Project description:The mechanisms of cognitive and learning effects of neonicotinoid pesticides were not fully understood. We examined the effects of acute exposure to a neonicotinoid pesticide, clothianidin (CLO) on gene expression profiles in the cellebellum of male mice at 10 weeks of age.

2024-04-03 | GSE251773 | GEO

Developmental effects of neonatal exposure to NOAEL-dose of neonicotinoid clothianidin on the gene expression profiles of hippocampus in male mice

Project description:The mechanisms of developmental neurotoxicity of neonicotinoid pesticides were not fully understood. We examined the effects of neonatal exposure to a neonicotinoid pesticide, clothianidin (CLO) on gene expression profiles of the hippocampus in male mice at 3 or 10 weeks of age.

2022-11-23 | GSE218520 | GEO

Effects of sub-acute exposure of NOAEL-dose neonicotinoid clothianidin on the gene expression profiles of cerebral cortex and hippocampus in male mice

Project description:Neonicotinoid pesticides cause behavioral abnormalities in mammals, raising concerns about their effects on neural function. We investigated effects of sub-acute exposure to a neonicotinoid pesticide, clothianidin (CLO) on gene expression profiles of the cerebral cortex and hippocampus in male mice

2022-01-08 | GSE193245 | GEO

Stimulative effect of low-dose neonicotinoid pesticide, clothianidin on human neuroblastoma SH-SY5Y cells by disrupting intracellular signaling

Project description:Neonicotinoids are one of most widely used pesticides targeting nicotinic acetylcholine receptors (nAChRs) of insects and suspected to have adverse effects on mammals by laboratory testing on rodents. Recent epidemiological evidence revealed the increasing amounts of neonicotinoids detected from human samples, rising a critical question whether neonicotinoids affect to human health. We investigated potential effects of a neonicotinoid pesticide, clothianidin (CTD) on human neuroblastoma SH-SY5Y cells as a model of nervous systems of human. Transcriptional analyses using GeneChip system were also performed to understand the effects of CTD on global gene expression.

2019-02-06 | GSE126103 | GEO

Effects of in utero and lactational exposure to low-dose neonicotinoid clothianidin on the gene expression profiles of the ovary in 3 weeks old mice

Project description:Neonicotinoid pesticides which were developed newly since the 1980s are chemically similar to nicotine. Prenatal and lactational exposure to neonicotinoid pesticides has been shown to cause reproductive toxicity in males, but not yet in female mice. We investigated effects of in utero and lactational exposure to a neonicotinoid pesticide, clothianidin (CLO) on gene expression profiles of the ovary in 3 weeks old mice.

2021-01-01 | GSE164099 | GEO

Genetics of tolerance in honey bees to the neonicotinoid clothianidin.

Project description:The effects of neonicotinoid insecticides (NNIs) on honey bee health is intensely debated, with numerous studies showing negative effects of exposure, while others report no such effects. Understanding the cause of these differences is critical for developing evidence-based policy on the use of NNIs. We carried out experiments to study the genetic and molecular basis of NNI tolerance in honey bees, which may underlie the discrepancies observed in the literature. We discovered that worker survival post-exposure to an acute oral dose of clothianidin is heritable (H2=37.8%).

2023-03-01 | GSE216021 | GEO

Stimulative effect of low-dose neonicotinoid pesticide, clothianidin on human neuroblastoma SH-SY5Y cells by disrupting intracellular signaling

Project description:Stimulative effect of low-dose neonicotinoid pesticide, clothianidin on human neuroblastoma SH-SY5Y cells by disrupting intracellular signaling

| PRJNA521023 | ENA

Genetics of tolerance in honey bees to the neonicotinoid clothianidin.

Project description:Genetics of tolerance in honey bees to the neonicotinoid clothianidin.

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Expression data in response to neonicotinoid insecticides

Project description:Neonicotinoid insecticides control crop pests based on their action as agonists at the insect nicotinic acetylcholine receptor which accepts chloropyridinyl- and chlorothiazolyl- analogs almost equally well. In some cases, these compounds have also been reported to enhance plant vigor and (a)biotic stress tolerance, independent of their insecticidal function. However, this mode of action has not been specifically defined. Using Arabidopsis thaliana, we show that the neonicotinoid compounds, imidacloprid (IMI) and clothianidin (CLO), via their 6-chloropyridinyl-3-carboxylic acid and 2-chlorothiazolyl-5-carboxylic acid metabolites, respectively, induce salicylic acid (SA) – associated plant responses. SA is a phytohormone best known for its role in plant defense against pathogens and as an inducer of systemic acquired resistance; however, it can also modulate abiotic stress responses. These neonicotinoids effect a similar global transcriptional response to that of SA including genes involved in (a)biotic stress response. Furthermore, similar to SA, IMI and CLO induce systemic acquired resistance resulting in reduced growth of a powdery mildew pathogen. The action of CLO induces the endogenous synthesis of SA via the SA biosynthetic enzyme ICS1, with ICS1 required for CLO-induced accumulation of SA, expression of the SA marker PR1, and fully enhanced resistance to powdery mildew. In contrast, the action of IMI does not induce endogenous synthesis of SA. Instead, IMI is further bioactivated to 6-chloro-2-hydroxypyridinyl-3-carboxylic acid, which is shown here to be a potent inducer of PR1 and inhibitor of SA-sensitive enzymes. Thus, via different mechanisms, these chloropyridinyl- and chlorothiazolyl- neonicotinoids induce SA responses associated with enhanced stress tolerance. response to neonicotinoid insecticides

2010-09-13 | E-GEOD-20188 | biostudies-arrayexpress

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