Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA sensing induced by chromosome missegregation augments anti-tumor immunity VI

ABSTRACT: RNA sensing induced by chromosome missegregation augments anti-tumor immunity VI

PROVIDER: PRJNA1183430 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

RNA sensing induced by chromosome missegregation augments anti-tumor immunity I

Project description:RNA sensing induced by chromosome missegregation augments anti-tumor immunity I

| PRJNA1183421 | ENA

RNA sensing induced by chromosome missegregation augments anti-tumor immunity II

Project description:RNA sensing induced by chromosome missegregation augments anti-tumor immunity II

| PRJNA1183422 | ENA

RNA sensing induced by chromosome missegregation augments anti-tumor immunity V

Project description:RNA sensing induced by chromosome missegregation augments anti-tumor immunity V

| PRJNA1183427 | ENA

RNA sensing induced by chromosome missegregation augments anti-tumor immunity IV

Project description:RNA sensing induced by chromosome missegregation augments anti-tumor immunity IV

| PRJNA1183428 | ENA

RNA sensing induced by chromosome missegregation augments anti-tumor immunity III

Project description:RNA sensing induced by chromosome missegregation augments anti-tumor immunity III

| PRJNA1183429 | ENA

RNA sensing induced by chromosome missegregation augments anti-tumor immunity VI

Project description:We demonstrate that dsRNA is significantly accumulated in cancer cells following pharmacologic induction of micronuclei, stimulating MAVS-mediated dsRNA sensing in conjunction with the cGAS/STING pathway. Activation of cytosolic dsRNA sensing co-operates with dsDNA sensing to up-regulate immune cell migration and antigen-presenting machinery. Tracing of dsRNA-sequence identity revealed that dsRNA-forming transcripts are predominantly generated from non-exonic regions, particularly in locations proximal to genes exhibiting high chromatin accessibility. Activation of this pathway by pulsed Monopolar Spindle 1 (MPS1) kinase inhibitor therapy, which potently induces micronuclei formation, thus induces cytoplasmic dsRNA-sensing and promotes anti-tumor immunity mediated by type I interferon signaling and cytotoxic lymphocyte activation in vivo. Taken together, these findings reveal a novel aspect of the dsRNA-sensing pathway in enhancing the anti-tumor efficacy of drugs that promote genomic instability and micronuclei formation, facilitating cancer immunogenicity.

2024-11-12 | GSE281352 | GEO