Project description:Factors impacting target-enriched long-read sequencing of resistomes and mobilomes
| PRJNA1081843 | ENA
Project description:Labor-OME project: Characterizing agricultural microbiomes, resistomes, and mobilomes on the skin surface of swine workers and swine
| PRJNA987158 | ENA
Project description:Exploring Resistomes from Viable Isolates in First Nation Community of Manitoba
Project description:Evaluation of pretreatment gene expression profiling features in elderly CLL patients; correlation with clinical outcome Evaluation of pretreatment gene expression profiling features in elderly CLL patients enrolled in a clinical trial; correlation with clinical outcome
Project description:We implemented an integrative systems-level analysis of multi-region postmortem human brain proteomics derived from the Religious Order and Rush Memory and Aging Project (ROSMAP) to identify proteins and pathways significantly altered in resilient cases. ROSMAP is an information-rich longitudinal cohort-based study in which participants enroll without dementia, undergo annual cognitive and clinical assessments and donate their brains at death (12). Multiplex tandem mass tag mass spectrometry (TMT-MS)-based proteomic data was implemented for a correlation network analysis. Data from an independent brain proteome wide association study (PWAS) of cognitive trajectory was integrated with the brain network to robustly prioritize protein communities associated with cognitive resilience. This revealed proteins linked to synaptic biology and cellular energetics. Neuritin (NRN1) was prioritized as a hub that co-expressed with a community of proteins with high correlation to cognitive stability in life and is known for important roles in synaptic maturation and stability.
2023-07-20 | PXD040224 | Pride
Project description:Genetic analysis of oligo-metastatic breast cancer: correlation with clinical outcomes
| PRJNA743504 | ENA
Project description:Exploratory Study on the Ocular Surface Microbiome and Correlation to Clinical Parameters
