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Gene expression profiles in human bronchial epithelial cells exposure to cellulose nanofibrils and microcrystalline cellulose

ABSTRACT: Gene expression profiles in human bronchial epithelial cells exposure to cellulose nanofibrils and microcrystalline cellulose

PROVIDER: PRJNA1186676 | ENA |

REPOSITORIES: ENA

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Gene expression profiles in human bronchial epithelial cells exposure to cellulose nanofibrils and microcrystalline cellulose

Project description:To evaluate the biological impact of cellulose nanofibrils (CNFs) at the transcriptional level, we conducted whole-genome microarray analyses on human bronchial epithelial cells (BEAS-2B) exposed to CNFs with different physicochemical properties. The results were compared with those from exposures to microcrystalline cellulose (MCC).

2024-11-20 | GSE282018 | GEO

Gene expression profiles in rat alveolar macrophages exposure to cellulose nanofibrils, microcrystalline cellulose, and lipopolysaccharide.

Project description:To assess the biological impact of cellulose nanofibrils (CNFs) at the transcriptional level, we conducted whole-genome microarray analyses on rat alveolar macrophages (NR8383) exposed to CNFs with varying physicochemical properties. The findings were compared with those from exposure to microcrystalline cellulose (MCC) and lipopolysaccharide (LPS).

2024-03-31 | GSE241791 | GEO

Gene expression profiles in rat alveolar macrophages exposure to cellulose nanofibrils, microcrystalline cellulose, and lipopolysaccharide.

Project description:Gene expression profiles in rat alveolar macrophages exposure to cellulose nanofibrils, microcrystalline cellulose, and lipopolysaccharide.

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Gene expression profiles in rat lung following intratracheal instillation with cellulose nanofibrils and multi-walled carbon nanotubes

Project description:To evaluate the biological effects at the transcriptional level of manufactured nanomaterials, whole genome microarray analysis of rat lungs intratracheally instilled with cellulose nanofibrils (CNFs) with different physicochemical properties or multi-walled carbon nanotubes (MWCNTs) were performed.

2020-07-09 | GSE154013 | GEO

Gene expression profiles in the lung following intratracheal instillation of cellulose nanofibrils and multi-walled carbon nanotubes in a murine COPD model

Project description:To evaluate the transcriptional-level biological effects of manufactured nanomaterials, a whole-genome microarray analysis was performed on the lungs of a murine chronic obstructive pulmonary disease (COPD) model. Mice were intratracheally instilled with cellulose nanofibrils (CNFs) or multi-walled carbon nanotubes (MWCNTs).

2024-12-10 | GSE283931 | GEO

RNA-seq human bronchial epithelial cells THC Exposure

Project description:RNA-seq human bronchial epithelial cells THC Exposure

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Acute and Chronic Environmental Tobacco Smoke Condensate Exposure to Primary Human Bronchial Epithelial Cells

Project description:The goal was to assess global gene expression changes in primary human bronchial epithelial cells exposed to environmental tobacco smoke (ETS) condensate. ETS-C was standardized by HPLC analysis and two timepoints of exposure in two different donor bronchial epithelial cell populations were assessed. These findings demonstrate that even short exposure (4.5 h) to ETS is sufficient to induce a stress response, as reflected by decreased antioxidant levels, induced HSP family members, and modulation of the family of glutathione metabolism enzymes in primary human lung cells. Upon longer exposures (48 h) with ETS-condensate, bronchial epithelial cells arrest at the G2/M phase of the cell cycle. Taken together, these data support a stress-induced state in primary human bronchial epithelial cells that culminates in cell cycle arrest. Keywords: time course, comparative, stress response

2006-12-25 | GSE4234 | GEO

Transcription profiling of human bronchial epithelial cells following exposure to whole cigarette smoke

Project description:In this analysis we have used gene expression measurements form human bronchial epithelial cells following exposure to whole cigarette smoke.

2009-03-11 | E-MEXP-1512 | biostudies-arrayexpress

RNA-seq human bronchial epithelial cells THC Exposure

Project description:Human bronchial epithelial cells transcriptomes sequenced using RNA-seq

2024-10-25 | GSE159489 | GEO

The impact of dietary cellulose on transcriptional profiles of colonic epithelial cells during inflammation.

Project description:Purpose: Although dietary cellulose is considered health promoting, there is still a lack of understanding of cellular and molecular mechanisms. The aim of this study was to shed light on possible effects of the fiber on key players in intestinal homeostasis, including intestinal epithelial cells. Method: Mice were fed a diet containing cellulose as the only source of fiber (CD, control diet) or a fiber free diet (FFD, fiber-free diet) for four weeks and then treated with dextran sulphate sodium in the drinking water for five days. To ensure that gene signatures were derived from colonic epithelial cells and not from contaminating lymphocytes, RAG1 KO mice deficient in intraepithelial lymphocytes were used. Results: The analysis of differential expressed genes of colonic epithelial cells revealed multiple effects of dietary cellulose on the transcriptional profiles. In addition, cellulose caused a distinct clustering when comparing signature genes of different epithelial cell types. Conclusion: This study demonstrated that dietary cellulose impacts transcriptional programs in colonic epithelial cells during inflammation.

2021-05-31 | GSE151136 | GEO

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