Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Study on recurrent spontaneous abortion induced by FABP5 downregulation

PROVIDER: PRJNA1189276 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31439825_1.fastq.gz	Fastqsanger.gz
	SRR31439825_2.fastq.gz	Fastqsanger.gz
	SRR31439826_1.fastq.gz	Fastqsanger.gz
	SRR31439826_2.fastq.gz	Fastqsanger.gz
	SRR31439827_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Epigenome analysis of decidua tissues from unexplained recurrent spontaneous abortion patients and controls with induced abortions

Project description:Genome wide DNA methylation profiling of decidua samples from unexplained recurrent spontaneous abortion patients and controls with induced abortions. The Infinium Human Methylation 850K BeadChip was used to obtain DNA methylation profiles across approximately 853,307 CpGs in decidua samples . Samples included 2 normal pregnant women (non-medical reasons for abortion) and 4 unexplained recurrent spontaneous abortion patients.

2018-07-12 | GSE113600 | GEO

Mouse placenta in spontaneous abortion

Project description:Genetic profiles of mouse placenta were examined especially at the implantation sites of causing spontaneous abortion at day 14.5 of pregnancy. There is a number of the suffered patients from the recurrent spontaneous abortion by unknown causes. It is an important process to understand genetic profiles in the abortion placentas for the investigation of specific causes to induce rejection of normal embryos from the maternal attack. Our study was carried out on the laboratory mice targeted spontaneous abortion to approximate human disease models.

2010-08-21 | GSE23737 | GEO

Project description:transcriptome sequencing of unexplained recurrent spontaneous abortion

| PRJNA771930 | ENA

Real-time quantitative PCR analysis of microRNAs in serum

Project description:Human serum samples were collected from patients with history of three or more recurrent spontaneous abortion and non- pregnant women with two or more successful deliveries. Chlamydia trachomatis infection was detected in the samples collected from the patients and real time PCR was perform to study the expression of microRNA genes in these patients.

2022-04-28 | GSE201656 | GEO

Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk

Project description:Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, compared to healthy controls, display reduced succinate dehydrogenase complex iron sulfur subunit (SDHB) DNA methylation, elevated SDHB expression, and reduced succinate levels, indicating that low succinate levels correlate with RSA. Moreover, we find high succinate levels in early pregnant women are correlated with successful embryo implantation. SDHB promoter methylation recruited MBD1 and excluded c-Fos, inactivating SDHB expression and causing intracellular succinate accumulation which mimicked hypoxia in extravillous trophoblasts cell lines JEG3 and HTR8 via the PHD2-VHL-HIF-1α pathway; however, low succinate levels reversed this effect and increased the risk of abortion in mouse model. This study reveals that abnormal metabolite levels inhibit extravillous trophoblast function and highlights an approach for RSA intervention.

2021-10-06 | MTBLS2148 | MetaboLights

Project description:Transcriptome sequencing of decidua in patients with unexplained recurrent spontaneous abortion

| PRJNA819201 | ENA

Epigenome analysis of decidua tissues from unexplained recurrent spontaneous abortion patients and controls with induced abortions

Project description:Epigenome analysis of decidua tissues from unexplained recurrent spontaneous abortion patients and controls with induced abortions

| PRJNA453194 | ENA

Project description:Small RNA sequencing of decidua in patients with unexplained recurrent spontaneous abortion

| PRJNA819210 | ENA

miR-381-3p contribution in mouse spontaneous abortion via targeting VEGFA

Project description:Recurrent spontaneous abortion (RSA) affects 1-5% of pregnant women, yet the mechanisms behind the disease remain unknown. It is well acknowledged that insufficient blood flow and placental abnormalities are key factors contributing to RSA. The abortive mouse model was constructed by intraperitoneal injection of β2-GPI. miRNA expression profiles in placental tissues of aborted and normal pregnant mice were detected by high-throughput sequencing. We found that miR-381-3p was highly expressed in the placenta of aborted mice and may bind to VEGFA

2025-01-20 | GSE286463 | GEO

RNA sequencing analysis of decidua tissues from unexplained recurrent spontaneous abortion patients and controls with induced abortions

Project description:RNA sequencing analysis of decidua tissues from unexplained recurrent spontaneous abortion patients and controls with induced abortions

| PRJNA453989 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data