Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of Vitamin D Modulation on the TH2 Cell Transcriptomic Landscape

ABSTRACT: Effect of Vitamin D Modulation on the TH2 Cell Transcriptomic Landscape

PROVIDER: PRJNA1191457 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31534500_1.fastq.gz	Fastqsanger.gz
	SRR31534500_2.fastq.gz	Fastqsanger.gz
	SRR31534501_1.fastq.gz	Fastqsanger.gz
	SRR31534501_2.fastq.gz	Fastqsanger.gz
	SRR31534502_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 80

Similar Datasets

Effect of Vitamin D Modulation on the TH2 Cell Transcriptomic Landscape

Project description:Effect of Vitamin D Modulation on the TH2 Cell Transcriptomic Landscape

| PRJNA1191048 | ENA

Effect of Vitamin D Modulation on the TH2 Cell Transcriptomic Landscape

Project description:This dataset examines the transcriptional effects of vitamin D deficiency in TH2 cells isolated from Mus musculus (C57BL/6 strain). Vitamin D-deficient mice were bred and maintained under UV-free conditions with a vitamin D-depleted diet. TH2 cells from these mice (N=7) were compared to TH2 cells from wild-type mice (N=3) to assess the impact of chronic vitamin D deficiency on gene expression. RNA-seq was used to generate raw gene-level counts.

2024-11-27 | GSE283020 | GEO

Effect of Vitamin D Modulation on the TH2 Cell Transcriptomic Landscape

Project description:This dataset profiles the transcriptional response of in vitro polarized TH2 cells treated with calcitriol (active vitamin D) and vehicle controls. RNA-seq was used to identify differentially expressed genes influenced by vitamin D signaling. This study provides insight into the molecular mechanisms through which vitamin D modulates immune responses in TH2 cells.

2024-11-27 | GSE282941 | GEO

Effect of ASB2 deletion on gene expression in non-stimulated and stimulated mouse Th2 lymphocytes

Project description:Because ASB2a-mediated degradation of filamin A and filamin B could be involved in the modulation of Th2 lymphocyte signaling and thus in the regulation of Th2-specific genes, the transcriptomic signatures of ctrl and ASB2a-deficient Th2 lymphocytes were established by RNA-seq. We here report no impact of ASB2a loss and filamin A/filamin B accumulation on the transcriptomic program of Th2 lymphocytes.

2024-09-23 | GSE251847 | GEO

Vitamin D modulation of innate immune signalling in Dendritic Cells

Project description:Vitamin D is widely reported to inhibit innate immune signalling and dendritic cell (DC) maturation, leading to attenuation of DC mediated T cell activation as a potential immunoregulatory mechanism to guard against autoimmunity and immmunopathology. It is not known whether vitamin D has global or gene specific effects on transcriptional responses downstream of innate immune stimulation. In order to address this question, we used genome-wide transcriptional profiling of monocyte derived DC differentiated in the presence and absence of vitamin D, and then stimulated with and without lipopolysaccharide for four hours.

2016-10-03 | E-MTAB-4883 | biostudies-arrayexpress

Vitamin D treatment of M.tb. infected macrophages

Project description:As macrophages are the primary site of Mtb infection and are sites of vitamin D signaling, we have used these cells to understand the molecular mechanisms underlying modulation of the immune response by the hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D). Microarrays were used to measure the changes in gene expression induced by 1,25D treatment of H37Rv-infected THP-1 cells

2013-11-28 | GSE52819 | GEO

The Effect of Steroid and ERa agonism on Th2 cells

Project description:Allergic asthma is a T helper 2 (Th2) cell-associated inflammatory disease, driven by cytokines such as IL-4, IL-5, and IL-13. Th2 cells express the G-protein-coupled receptor CRTh2, a receptor for prostaglandin D2 (PGD2) that influences Th2 function and survival. Inhaled glucocorticosteroids are the primary treatment of allergic asthma and improve asthma symptoms by inhibiting Th2 cytokine production. Women are more likely than men to have severe asthma and to have symptoms requiring a hospital visit. These findings lead us to consider a mechanism by which female sex hormones could influence Th2 cell response to glucocorticosteroid. Using whole-mRNA sequencing, we examined gene expression in primary Th2 cells following exposure to glucocorticosteroids (0.1µM) in the presence or absence of an estrogen mimic, PPT (10µM).

2022-10-19 | GSE132699 | GEO

Vitamin D Receptor regulation of hepatic energy metabolism in zebrafish

Project description:Vitamin D deficiency and mutations in Vitamin D Receptor (VDR) are associated with liver disease and obesity, but the functions of vitamin D signaling in metabolism are poorly understood. Though vitamin D signaling is best known for its functions in mineral homeostasis and skeleton calcification in terrestrial vertebrates, this is unlikely to be the evolutionary function of vitamin D signaling. We utilize tissue-specific genetic modulation of Vdr signaling to investigate the function of the vitamin D endocrine system in zebrafish. We find that hepatocyte Vdr regulates organismal response to nutritional cues and coordinates hepatic and organismal energy metabolism by balancing energy storage and tissue growth.

2023-04-20 | GSE217120 | GEO

Vitamin D treatment of M.tb. infected macrophages

2013-11-28 | E-GEOD-52819 | biostudies-arrayexpress

Effect of Th2 cytokines on AEC2 transcriptome

Project description:Effect of Th2 cytokines on AEC2 transcriptome

| PRJNA597774 | ENA