Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Antibiotic resistome in key basins with different water sources

PROVIDER: PRJNA1192725 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31564080_1.fastq.gz	Fastqsanger.gz
	SRR31564080_2.fastq.gz	Fastqsanger.gz
	SRR31564081_1.fastq.gz	Fastqsanger.gz
	SRR31564081_2.fastq.gz	Fastqsanger.gz
	SRR31564082_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 22

Similar Datasets

Project description:Antibiotic resistome and microbiom in different districts.

| PRJNA623286 | ENA

Project description:Antibiotic resistome in two water-diversion lakes, China

| PRJNA1132744 | ENA

Broad-spectrum adaptive antibiotic resistance associated with Pseudomonas aeruginosa mucin-dependent surfing motility

Project description:Surfing motility is a novel form of surface adaptation exhibited by the nosocomial pathogen, Pseudomonas aeruginosa, in the presence of the glycoprotein mucin that is found in high abundance at mucosal surfaces especially the lungs of cystic fibrosis and bronchiectasis patients. Here we investigated the adaptive antibiotic resistance of P. aeruginosa under conditions in which surfing occurs compared to cells undergoing swimming. P. aeruginosa surfing cells were significantly more resistant to several classes of antibiotics including aminoglycosides, carbapenems, polymyxins, and fluroquinolones. This was confirmed by incorporation of antibiotics into growth medium, which revealed a concentration-dependent inhibition of surfing motility that occurred at concentrations much higher than those needed to inhibit swimming. To investigate the basis of resistance, RNA-Seq was performed and revealed that surfing influenced the expression of numerous genes. Included amongst genes dysregulated under surfing conditions were multiple genes from the Pseudomonas resistome, which are known to affect antibiotic resistance when mutated. Screening transposon mutants in these surfing-dysregulated resistome genes revealed that several of these mutants exhibited changes in susceptibility to one or more antibiotics under surfing conditions, consistent with a contribution to the observed adaptive resistance. In particular, several mutants in resistome genes, including armR, recG, atpB, clpS, nuoB, and certain hypothetical genes such as PA5130, PA3576 and PA4292, showed contributions to broad-spectrum resistance under surfing conditions and could be complemented by their respective cloned genes. Therefore, we propose that surfing adaption led to extensive multidrug adaptive resistance as a result of the collective dysregulation of diverse genes.

2018-06-26 | GSE110044 | GEO

Project description:Long-term Different Land Uses Differentiate Soil Antibiotic Resistome

| PRJNA924992 | ENA

Metaproteomic analysis of gut resistome in the cecal microbiota of fattening pigs raised without antibiotics

Project description:Improper use of antibiotics in swine could reduce commensal bacteria and possibly increase pathogen infections via the gut resistome. This study aimed to compare the metaproteomic profiles of gut resistome and related metabolism in the cecal microbiota of fattening pigs raised under antibiotic-free (ABF) conditions with those of ordinary industrial pigs (CTRL).

2023-10-09 | PXD037218 | JPOST Repository

Project description:Antibiotic resistome in a full-scale drinking water treatment plant

| PRJNA1181661 | ENA

Project description:fractionated antibiotic resistome in wastewater

| PRJNA687102 | ENA

Project description:Antibiotic resistome in rural groundwater

| PRJNA879895 | ENA

Metagenomics on pika

Project description:Wildlife carcass and antibiotic resistome

| PRJEB54009 | ENA

16S on pika

Project description:Wildlife carcass and antibiotic resistome