Project description:We report that liver nodules from 5/8 (62.5%) male and 4/5 (80%) female Gnmt-/- mice were diagnosed as having HCC. Microarray analysis showed that genes involved in the following pathways were deregulated in different stages of tumorigenesis: Methylation, metabolism, signal transduction, cell proliferation, and cell adhesion. This study reveals that GNMT plays an important role in the prevention of hepatotumorigenesis through regulating detoxification pathways. We postulate that GNMT is a stress-responsive protein and its expression may account for the gender difference of the susceptibility to liver cancer. Liver tissues from aflatoxin B1 (AFB1)-treated wild-type or Gnmt knockout mice at 11weeks old were used for RNA extraction and hybridization on Affymetrix microarrays. Total RNA were mixed in equal proportion from 3 mice.

2009-10-02 | E-GEOD-18218 | biostudies-arrayexpress

E-GEOD-49804

Project description:Expression data from dexamethasone treated mouse embryonic neural progenitor/stem cells isolated from wild type C57Bl/6 or caveolin-1 knockout mice

2015-07-27 | E-GEOD-49804 | ExpressionAtlas

E-GEOD-44356

Project description:Expression data from wild-type and HMGN1 knockout mice injected with N-nitrosodiethylamine

2015-07-10 | E-GEOD-44356 | ExpressionAtlas

Mus musculus

Project description:Expression data from GNMT knockout mice in Hepatocytes and OKER cell lines

| PRJNA150211 | ENA

E-GEOD-54774

Project description:Expression data from mice on a high fat, high carbohydrate diet treated with exenatide

2015-08-04 | E-GEOD-54774 | ExpressionAtlas

E-GEOD-57015

Project description:Hippocampal expression data from FTY720- and vehicle-treated SCID mice following fear consolidation testing