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Interaction of the endogenous antibody response with activating FcgRs enhance control of Mayaro virus through monocytes

ABSTRACT: Interaction of the endogenous antibody response with activating FcgRs enhance control of Mayaro virus through monocytes

PROVIDER: PRJNA1205560 | ENA |

REPOSITORIES: ENA

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Interaction of the endogenous antibody response with activating FcgRs enhance control of Mayaro virus through monocytes

Project description:Mayaro virus (MAYV) is an emerging arbovirus. Previous studies have shown antibody Fc effector functions are critical for optimal monoclonal antibody-mediated protection against alphaviruses; however, the requirement of Fc gamma receptors (FcgRs) for protection during natural infection has not been evaluated. Here, we showed mice lacking activating FcgRs (FcRg-/-) developed prolonged clinical disease with more MAYV in joint-associated tissues. Viral clearance was associated with anti-MAYV cell surface binding antibodies rather than neutralizing antibodies. Lack of Fc-FcgR engagement increased the number of monocytes through chronic timepoints. Single cell RNA sequencing showed elevated levels of pro-inflammatory monocytes in joint-associated tissue with increased MAYV RNA present in FcRg-/- monocytes and macrophages. Transfer of FcRg-/- monocytes into wild type animals was sufficient to increase virus in joint-associated tissue. Overall, this study suggests that engagement of antibody Fc with activating FcgRs promotes protective responses during MAYV infection and prevents a pro-viral role for monocytes.

2025-02-05 | GSE285678 | GEO

CD4 T cell activating neoantigens enhance personalized cancer vaccine efficacy

Project description:CD4 T cell activating neoantigens enhance personalized cancer vaccine efficacy

| PRJNA1026585 | ENA

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

Project description:De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

| PRJNA417713 | ENA

Transcriptome profile of liver tissue in CD95 activating antibody-treated mice

Project description:In order to identify the effects of CD95 activating antibody on the transcriptome of liver tissue, we performed RNAseq experiments Transcriptome analysis of the liver of mice trated with CD95 activating antibody, compared with liver of mice trated with saline.

2018-11-21 | GSE101822 | GEO

Probiotic Bacteria-Released Extracellular Vesicles Enhance Macrophage Phagocytosis in Polymicrobial Sepsis Through Activating the FPR1/2 Pathway

Project description:Probiotic Bacteria-Released Extracellular Vesicles Enhance Macrophage Phagocytosis in Polymicrobial Sepsis Through Activating the FPR1/2 Pathway

| PRJNA1148074 | ENA

Identification of small activating RNAs that enhance endogenous OCT4 expression in human mesenchymal stem cells.

Project description:Ectopic overexpression of transcription factors has been used to reprogram cell fate. For example, virus-mediated overexpression of four transcription factors OCT4, SOX2, MYC, and KLF4, known as Yamanaka factors, can convert somatic cells to induced pluripotent stem (iPS) cells. However, gene-specific switch-on of endogenous gene production without the use of foreign DNA remains a challenge. The small RNA machinery that comprised small RNAs and Argonaute proteins is known to silence gene expression, but can be repurposed to activate gene expression when directed to gene promoters, a phenomenon known as RNA activation or RNAa. By screening of dsRNAs targeting OCT4 promoter, we identified a small activating RNA (saRNA) that activated OCT4 expression in several types of human mesenchymal stem cells (MSCs). We found that saRNA-induced OCT4 activation can be further enhanced by a histone deacetylase inhibitor, valproic acid. Furthermore, introducing OCT4 saRNA in combination with viruses encoding the remaining three Yamanaka factors (SOX2, MYC, and KLF4) into MSCs led to the derivation of partially reprogrammed iPS cells. Findings from this study suggest that, with further optimization, RNAa can be a powerful tool to reprogram cell fate by inducing the expression of endogenous genes.

| S-EPMC4303016 | biostudies-literature

PARP inhibition induces cytotoxicity in mESCs by activating endogenous retroviruses.

Project description:PARP inhibition induces cytotoxicity in mESCs by activating endogenous retroviruses.

| PRJNA702474 | ENA

WAS enhance organohalides respiration

Project description:WAS enhance organohalides respiration

| PRJEB40323 | ENA

Genomic alterations activating KLF5

Project description:Genomic alterations activating KLF5

| PRJNA349438 | ENA

Effect of a CD28H agonistic monoclonal antibody on NK cells

Project description:Mature NK cell activation relies on a balance of activating, co-stimulatory and inhibitory receptors involved during target recognition. Immunotherapy strategies has been developed to finely tune this balance in order to enhance NK cell cytotoxic functions against cancer cells and secretory functions to enhance adaptative immunity activation. CD28H, a new member of the CD28 family, has been recently studied in T cells and on NK cells as a part of CD28H-CAR-NKL strategy. Given the impressive expression of CD28H molecule on circulating NK cells, we evaluated the use an anti-CD28H mAb on NK cell activation.

2024-10-24 | GSE152269 | GEO

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