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Tfr Cells Restrain Rejection of Kidney Allografts by Limiting Pro-Inflammatory Cytokines in B cells [scRNA-seq]

ABSTRACT: Tfr Cells Restrain Rejection of Kidney Allografts by Limiting Pro-Inflammatory Cytokines in B cells [scRNA-seq]

PROVIDER: PRJNA1207555 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31916783.fastq.gz	Fastqsanger.gz
	SRR31916783_1.fastq.gz	Fastqsanger.gz
	SRR31916783_2.fastq.gz	Fastqsanger.gz
	SRR31916784.fastq.gz	Fastqsanger.gz
	SRR31916785.fastq.gz	Fastqsanger.gz

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Tfr Cells Restrain Rejection of Kidney Allografts by Limiting Pro-Inflammatory Cytokines in B cells [scRNA-seq]

Project description:Pathogenic antibodies produced by alloreactive B cells mediate antibody-mediated rejection (ABMR) after kidney transplantation, but the mechanisms controlling these antibodies remain poorly understood. Follicular Regulatory T (Tfr) cells modulate follicular helper T (Tfh) cell-mediated B cell responses but their roles in controlling alloreactive antibody are unknown. Here, we studied the developmental signals and functions of Tfr cells in allogeneic kidney transplantation. We show that costimulatory blockade alters the development of Tfr cells disproportionately by decreasing germinal center (GC)-like Tfr cells and increasing follicular-like Tfr cells. Functionally, Tfr cell deletion resulted in accelerated rejection and increases in donor-specific B cells in both draining lymph nodes and kidney allografts. Mechanistically, Tfr cell deletion increased GC B cell expression of pro-inflammatory cytokines such as IL-15. Neutralization of IL-15 compensated for the loss of Tfr cells and prolonged kidney transplant recipient survival. Together these data demonstrate the signals for Tfr cell development and how these cells restrain rejection by limiting alloreactive B cell responses.

2025-02-15 | GSE286055 | GEO

Tfr Cells Restrain Rejection of Kidney Allografts by Limiting Pro-Inflammatory Cytokines in B cells.

Project description:Tfr Cells Restrain Rejection of Kidney Allografts by Limiting Pro-Inflammatory Cytokines in B cells.

| PRJNA1210617 | ENA

Tfr Cells Restrain Rejection of Kidney Allografts by Limiting Pro-Inflammatory Cytokines in B cells.

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-02-15 | GSE286975 | GEO

Identification of microRNAs involved in acute rejection and spontaneous tolerance in murine hepatic allografts

Project description:Graft acceptance without the need for immunosuppressive drugs is the ultimate goal of transplantation therapy. In murine liver transplantation, allografts are accepted across major histocompatibility antigen complex barriers without the use of immunosuppressive drugs and constitute a suitable model for research on immunological rejection and tolerance. MicroRNA (miRNA) has been known to be involved in the immunological responses. In order to identify mRNAs in spontaneous liver allograft tolerance, miRNA expression in hepatic allografts was examined using this transplantation model. According to the graft pathological score and function, miR-146a, 15b, 223, 23a, 27a, 34a and 451 were upregulated compared with the expression observed in the syngeneic grafts. In contrast, miR-101a, 101b and 148a were downregulated. Our results demonstrated the alteration of miRNAs in the allografts and may indicate the role of miRNAs in the induction of tolerance after transplantation. Furthermore, our data suggest that monitoring the graft expression of novel miRNAs may allow clinicians to differentiate between rejection and tolerance. A better understanding of the tolerance inducing mechanism observed in murine hepatic allografts may provide a therapeutic strategy for attenuating allograft rejection.

2014-10-21 | GSE52164 | GEO

Identification of microRNAs involved in acute rejection and spontaneous tolerance in murine hepatic allografts

2014-10-21 | E-GEOD-52164 | biostudies-arrayexpress

RNA-Seq analysis of germinal center B cells from Tfr-depleted and control kidney transplant recipients

Project description:Assessment of transcriptional programs of germinal center B cells isolated from lymph nodes of Tfr-depleted (Tfr-DTR) and control (Tfr-Con) recipients post-transplantation to investigate the role of Tfr cells in kidney transplant rejection.

2025-02-15 | GSE286974 | GEO

Urinary Cell Transcriptomics and Acute Rejection in Human Kidney Allografts

Project description:Urinary Cell Transcriptomics and Acute Rejection in Human Kidney Allografts

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Transcriptional changes in kidney allografts with histology of antibody-mediated rejection

Project description:Transcriptional changes in kidney allografts with histology of antibody-mediated rejection

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Single Nucleus RNA Sequencing of Human Kidney Allografts with Cellular Rejection

Project description:Single Nucleus RNA Sequencing of Human Kidney Allografts with Cellular Rejection

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Landscape of innate immune system transcriptome and acute T-cell mediated rejection of human kidney allografts

Project description:Acute rejection of human allografts has been viewed mostly through the lens of adaptive immunity, and the intragraft landscape of innate immunity genes has not been characterized in an unbiased fashion. We did RNA sequencing of 34 kidney allograft biopsy specimens from 34 adult recipients; 16 were categorized as Banff acute T-cell mediated rejection (TCMR) and 18 as normal. Computational analysis of intragraft mRNA transcriptome identified significantly higher abundance of mRNA for pattern recognition receptors in TCMR compared to normal biopsies, as well as increased expression of mRNAs for cytokines, chemokines, interferons, and caspases. Intragraft levels of calcineurin mRNA were higher in TCMR biopsies suggesting under immunosuppression compared to normal biopsies. Cell-type enrichment analysis revealed higher abundance of dendritic cells and macrophages in TCMR biopsies. Damage associated molecular patterns, the endogenous ligands for pattern recognition receptors, as well markers of DNA damage were higher in TCMR. mRNA expression patterns supported increased calcium flux and indices of endoplasmic, cellular oxidative, and mitochondrial stress were higher in TCMR. Expression of mRNAs in major metabolic pathways were decreased in TCMR. Our global and unbiased transcriptome profiling identified heightened expression of innate immune system genes during an episode of TCMR in human kidney allografts.

2019-07-26 | GSE131179 | GEO

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