Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Chip-seq of Nrf2 in vehicle and DOPAC-treated CD8+ T cells

ABSTRACT: Chip-seq of Nrf2 in vehicle and DOPAC-treated CD8+ T cells

PROVIDER: PRJNA1210975 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR32004891_1.fastq.gz	Fastqsanger.gz
	SRR32004891_2.fastq.gz	Fastqsanger.gz
	SRR32004892_1.fastq.gz	Fastqsanger.gz
	SRR32004892_2.fastq.gz	Fastqsanger.gz
	SRR32004893_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 10

Similar Datasets

Chip-seq of Nrf2 in vehicle and DOPAC-treated CD8+ T cells

Project description:To further investigate how DOPAC regulates mitophagy in CD8+ T cells by rescuing Nrf2 from Keap1-driven degradation, we conducted chromatin immunoprecipitation sequencing (ChIP-seq) to identify genome-wide Nrf2-binding loci.

2025-01-23 | GSE287017 | GEO

CUT&Tag-seq of H3k27me3 in vehicle and DOPAC-treated CD8+ T cells

Project description:To investigate epigenetic alterations in vehicle and DOPAC-treated CD8+ T cells

2025-08-16 | GSE305082 | GEO

RNA-seq of control and DOPAC-treated CD8+ T cells in vitro

Project description:To investigate the effect of DOPAC on CD8+ T cells function, CD8+ T cells were treated with DOPAC for bulk RNA sequcecing.

2025-01-21 | GSE287296 | GEO

CUT&Tag-seq of H3k27me3 in vehicle and DOPAC-treated CD8+ T cells

Project description:CUT&Tag-seq of H3k27me3 in vehicle and DOPAC-treated CD8+ T cells

| PRJNA1304407 | ENA

scRNA-seq of tumor-infiltrating CD45+ cells from B16-F10 tumor-bearing mice treated with vehicle and DOPAC.

Project description:To investigate how DOPAC suppresses tumors in vivo, we performed single-cell RNA sequencing (scRNA-seq) on CD45+ cells isolated from the tumor tissues of B16-F10-bearing mice.

2025-01-23 | GSE287577 | GEO

RNA-seq of control and DOPAC-treated CD8+ T cells in vitro

Project description:RNA-seq of control and DOPAC-treated CD8+ T cells in vitro

| PRJNA1212056 | ENA

The Prostacyclin Receptor is a NRF2-regulated Immune Checkpoint in CD8 T cells

Project description:Immune checkpoint inhibitor (ICI) therapies revitalize anti-cancer responses by intercepting protein-protein interactions between exhausted CD8 T (Tex) cells and cancer cells (e.g. PD-1:PD-L1). However, up to 50% of patients receiving ICIs relapse, warranting further interrogation of the underpinnings of Tex. We conducted RNA-seq meta-analysis of Tex versus effector (Teff) mouse CD8 T cells, and highlighted NRF2 transcriptional targets as the most upregulated gene set in Tex cells. LCMV or cancer inoculation of mice bearing NRF2 hyperactive—or Keap1-/- (NRF2 negative regulator)—T cells demonstrated that NRF2 drives Tex; evidenced by increased co-inhibitory marker (PD-1/TIM-3) expression and reduced cytokine (IFN-g/Granzyme-B) production. RNA-seq of Keap1-/- highlight Ptgir—which encodes the prostacyclin lipid receptor— as the most upregulated gene versus WT T cells. Accordingly, PTGIR knockout in NRF2-hyperactive/ Tex cells decreased PD-1/TIM-3 expression, increased cytokine production, and attenuated tumor growth. Our data underscore PTGIR as a NRF2-regulated Tex driver and illuminate an unconventional immune checkpoint class potentially based on protein-lipid interactions

2025-04-25 | PXD052688 | Pride

Chromatin accessibility analysis of tumor-infiltrating CD8+ T cells from tumor-bearing mice transferred Nrf2-deficient CD8+ T cells. [ATACseq]

Project description:To identify unique chromatin regions predicting the anti-tumor efficacy of Nrf2-deleted smart CD8+ T cell therapy, we performed an assay for transposase-accessible chromatin sequencing (ATAC-seq) using tumor-infiltrating CD8+ T cells from tumor-bearing mice transferred Nrf2-deficient CD8+ T cells. From the analysis of ATAC-seq data, we identified quantitatively distinct open regions of chromatin that distinguish Nrf2-deficient CD8+ T cells or WT CD8+ T cells.

2024-04-01 | GSE229990 | GEO

scRNA-seq of tumor-infiltrating CD45+ cells from B16-F10 tumor-bearing mice treated with vehicle and DOPAC.

Project description:scRNA-seq of tumor-infiltrating CD45+ cells from B16-F10 tumor-bearing mice treated with vehicle and DOPAC.

| PRJNA1213774 | ENA

ChIP-Seq analysis of NRF2 binding sites in human BEAS-2B cell line treated with sulforaphane or vehicle

Project description:Cellular oxidative and electrophilic stress triggers a protective response in mammals regulated by NRF2 (nuclear factor (erythroid-derived) 2-like; NFE2L2) binding to DNA-regulatory sequences near stress responsive genes. Studies using Nrf2-deficient mice suggest that hundreds of genes may be regulated by NRF2. To identify human NRF2-regulated genes, we conducted ChIP-sequencing experiments in human BEAS-2B cell line treated with the dietary isothiocyanate, sulforaphane (SFN) and carried out follow-up biological experiments on candidates.

2018-06-19 | GSE75812 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data